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Review
. 2023 Nov 17;15(6):2331-2333.
doi: 10.14336/AD.2023.1109.

ARID1a Gene as a Potential Early Marker to Tackle Endometriosis-Associated Ovarian Cancer

Pawel Kordowitzki  1   2 , Sylvia Mechsner  2 , Jalid Sehouli  2
Affiliations
Review

ARID1a Gene as a Potential Early Marker to Tackle Endometriosis-Associated Ovarian Cancer

Pawel Kordowitzki et al. Aging Dis. .

Abstract

The worries of women with endometriosis - a chronic gynecological disease affecting approximately 10% of women of childbearing age - about the increased risk of ovarian cancer are present worldwide. Endometriosis is a common, often painful, but benign gynecological disease that affects women. However, the pathogenesis remains elusive but is certainly multifactorial. Interestingly, endometriosis shares similarities with cancer. Therefore, women suffering from endometriosis fear an increased risk of ovarian cancer. In addition, these patients suffer from anxiety and depression. Previous studies have provided evidence that epithelial mutations in endometriosis or in the endometrium include certain inactivating mutations responsible for ovarian cancer, such as in the ARID1A gene.

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Conflict of interest statement

The Authors declare no Competing Financial or Non-Financial Interests.

Figures

Figure 1.
Figure 1.
Schematic representation of ARID1a mutation as potential early marker for malignant transformation of endometriosis and endometroid ovarian cancer initiation in women.
See this image and copyright information in PMC

References

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