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Review
. 2024 Feb;132(2):81-93.
doi: 10.1111/apm.13362. Epub 2023 Nov 29.

Bacteriophage-based approach for treatment of urinary tract infections: a quick outlook

Bartłomiej Grygorcewicz  1   2 , Marta Gliźniewicz  1 , Joanna Jabłońska  2 , Adrian Augustyniak  2   3   4 , Patrycja Olszewska  1 , Bartosz Wojciuk  5 , Dominika Miłek  1 , Natalia Serwin  1 , Artur Czajkowski  1 , Elżbieta Cecerska-Heryć  1   2 , Rafał Rakoczy  2 , Aneta Cymbaluk-Płoska  6
Affiliations
Review

Bacteriophage-based approach for treatment of urinary tract infections: a quick outlook

Bartłomiej Grygorcewicz et al. APMIS. 2024 Feb.

Abstract

Urinary tract infections (UTIs) are among the most common bacterial infections affecting millions worldwide. The increasing emergence of antibiotic-resistant bacteria has become a serious concern in managing UTIs. Therefore, there is a growing interest in using bacteriophages as an alternative or adjunct therapy for UTIs. Bacteriophages are viruses that infect and kill bacteria, making them a promising tool for treating UTIs caused by antibiotic-resistant bacteria. This article provides a quick outlook on using bacteriophages to treat UTIs. We summarize the current understanding of the biology of bacteriophages, the challenges associated with developing phage-based therapies, and the promising results of several case reports and clinical trials. We also highlight the potential of phage therapy as a valuable tool in the fight against antibiotic-resistant UTIs. This quick outlook on a bacteriophage-based approach for treating UTIs offers a timely and informative summary of the current research in this field.

Keywords: Antibiotic resistance; UTI; bacteriophages; phage therapy.

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References

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