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Review
. 2023 Oct-Dec;106(4):368504231215942.
doi: 10.1177/00368504231215942.

Biological properties of polycaprolactone and barium titanate composite in biomedical applications

Sabreen Waleed Ibrahim  1 , Thekra Ismael Hamad  2 , Julfikar Haider  3
Affiliations
Review

Biological properties of polycaprolactone and barium titanate composite in biomedical applications

Sabreen Waleed Ibrahim et al. Sci Prog. 2023 Oct-Dec.

Abstract

The ceramic-polymer composite materials are widely known for their exceptional mechanical and biological properties. Polycaprolactone (PCL) is a biodegradable polymer material extensively used in various biomedical applications. At the same time, barium titanate (BT), a ceramic material, exhibits piezoelectric properties similar to bone, which is essential for osseointegration. Furthermore, a composite material that combines the benefits of PCL and BT results in an innovative composite material with enhanced properties for biomedical applications. Thus, this review is organised into three sections. Firstly, it aims to provide an overview of the current research on evaluating biological properties, including antibacterial activity, cytotoxicity and osseointegration, of PCL polymeric matrices in its pure form and reinforced structures with ceramics, polymers and natural extracts. The second section investigates the biological properties of BT, both in its pure form and in combination with other supporting materials. Finally, the third section provides a summary of the biological properties of the PCLBT composite material. Furthermore, the existing challenges of PCL, BT and their composites, along with future research directions, have been presented. Therefore, this review will provide a state-of-the-art understanding of the biological properties of PCL and BT composites as potential futuristic materials in biomedical applications.

Keywords: Barium titanate; antibacterial; composite; cytotoxicity; osseointegration; polycaprolactone.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Crystalline structure of BT material.
Figure 2.
Figure 2.
A schematic representation of the four different crystalline structures of BaTiO3.
See this image and copyright information in PMC

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