Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Apr 1;109(4):1279-1284.
doi: 10.3324/haematol.2023.283884.

Comorbidity indices for prognostic evaluation in multiple myeloma: a comprehensive evaluation of the Revised Myeloma Comorbidity Index and other comorbidity indices with pro- and retrospective applications

Affiliations
Comment

Comorbidity indices for prognostic evaluation in multiple myeloma: a comprehensive evaluation of the Revised Myeloma Comorbidity Index and other comorbidity indices with pro- and retrospective applications

Katja Schoeller et al. Haematologica. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Comparison of risk group designation via R-MCI, IMWG, CCI and Mayo risk score, using retrospective versus prospective data. (A) Revised Myeloma Comorbidity Index (R-MCI), (B) International Myeloma Working Group (IMWG) frailty index, (C) Charlson Comorbidity Index (CCI) and (D) Mayo risk score compared between prospective and retrospective cohort.
Figure 2.
Figure 2.
Kaplan-Meier estimates for overall survival and progression-free survival (prospective cohort N=354) according to different comorbidity scores in prospective cohort. (A) Overall survival (OS) and (B) progression-free survival (PFS) for Revised Myeloma Comorbidity Index (R-MCI). (C) OS and (D) PFS for International Myeloma Working Group (IMWG) frailty index. (E) OS and (F) PFS for Charlson Comorbidity Index (CCI). (G) OS and (H) PFS for Mayo risk score.

Comment on

References

    1. Larocca A, Dold SM, Zweegman S, et al. . Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN). Leukemia. 2018;32(8):1697-1712. - PubMed
    1. Coulson AB, Royle K-L, Pawlyn C, et al. . Frailty-adjusted therapy in transplant non-eligible patients with newly diagnosed multiple myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III trial. BMJ Open. 2022;12(6):e056147. - PMC - PubMed
    1. Efficace F, Gaidano G, Petrucci MT, et al. . Association of IMWG frailty score with health-related quality of life profile of patients with relapsed refractory multiple myeloma in Italy and the UK: a GIMEMA, multicentre, cross-sectional study. Lancet Healthy Longev. 2022;3(9):e628-e635. - PubMed
    1. Pawlyn C, Khan AM, Freeman CL. Fitness and frailty in myeloma. Hematol Am Soc Hematol Educ Program. 2022;2022(1):337-348. - PMC - PubMed
    1. Scheubeck S, Ihorst G, Schoeller K, et al. . Comparison of the prognostic significance of 5 comorbidity scores and 12 functional tests in a prospective multiple myeloma patient cohort. Cancer. 2021;127(18):3422-3436. - PubMed