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Case Reports
. 2024 Jan-Feb;38(1):370-374.
doi: 10.1111/jvim.16954. Epub 2023 Nov 30.

Uroliths composed of antiviral compound GS-441524 in 2 cats undergoing treatment for feline infectious peritonitis

Marissa Allinder  1 , Beth Tynan  2 , Cara Martin  3 , Amelia Furbish  4 , Glenn Austin  5 , Joe Bartges  3 , Bianca N Lourenço  3
Affiliations
Case Reports

Uroliths composed of antiviral compound GS-441524 in 2 cats undergoing treatment for feline infectious peritonitis

Marissa Allinder et al. J Vet Intern Med. 2024 Jan-Feb.

Abstract

Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8-month-old female spayed domestic short-haired cat undergoing treatment for presumptive FIP with the antiviral nucleoside analog GS-441524 developed acute progressive azotemia. Abdominal ultrasound examination identified multifocal urolithiasis including renal, ureteral, and cystic calculi. Unilateral ureteral obstruction progressed to suspected bilateral ureteral obstruction and subcutaneous ureteral bypass (SUB) was performed along with urolith removal and submission for analysis. A 2-year-old male neutered domestic medium-haired cat undergoing treatment for confirmed FIP with GS-441524 developed dysuria (weak urine stream, urinary incontinence, and difficulty expressing the urinary bladder). This cat also was diagnosed sonographically with multifocal urolithiasis requiring temporary tube cystostomy after cystotomy and urolith removal. In both cases, initial urolith analysis showed unidentified material. Additional testing confirmed the calculi in both cats to be 98% consistent with GS-441524. Additional clinical studies are required to determine best screening practices for cats presented for urolithiasis during treatment with GS-441524.

Keywords: GS-441524; antivirals; coronavirus; feline; fip; urolith.

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Conflict of interest statement

Authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Indistinct radiopacities (arrow) within the urinary bladder depicted on a right lateral abdominal radiograph.
FIGURE 2
FIGURE 2
Case 1, cystolith from an 8‐month‐old female spayed domestic short‐haired cat presumptively diagnosed with feline infectious peritonitis and treated with GS‐441524. Louis C. Herring & Co.
FIGURE 3
FIGURE 3
Case 2 cystolith from a 2‐year‐old male neutered domestic medium‐haired cat diagnosed with feline infectious peritonitis and treated with GS‐441524. Louis C. Herring & Co.
See this image and copyright information in PMC

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