Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Feb 1;209(3):341-342.
doi: 10.1164/rccm.202310-1761LE.

Use FEV1/FVC Z-Score Staging to Minimize Sex and Age Bias in Staging Chronic Obstructive Pulmonary Disease

Brian L Graham  1
Affiliations
Comment

Use FEV1/FVC Z-Score Staging to Minimize Sex and Age Bias in Staging Chronic Obstructive Pulmonary Disease

Brian L Graham. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Upper panel: The staging of airflow obstruction in chronic obstructive pulmonary disease (COPD) by FEV1/FVC (STAR) COPD stages (1) overlaid on the distribution of FEV1/FVC for 75-year-old males (blue lines) and 35-year-old females (orange lines) in the reference population (2). Lower panel: STAR COPD stages for FEV1/FVC from 0.7 to 0.4 as a function of the equivalent z-scores (males shown in blue; females shown in orange) compared with COPD staging using z-scores (black lines) for both males and females.
See this image and copyright information in PMC

Comment in

  • Reply to Neder, to Ogata et al., and to Graham.
    Bhatt SP, Nakhmani A, Fortis S, Strand MJ, Silverman EK, Sciurba FC, Bodduluri S. Bhatt SP, et al. Am J Respir Crit Care Med. 2024 Feb 1;209(3):343-345. doi: 10.1164/rccm.202311-2016LE. Am J Respir Crit Care Med. 2024. PMID: 38033318 Free PMC article. No abstract available.

Comment on

References

    1. Bhatt SP, Nakhmani A, Fortis S, Strand MJ, Silverman EK, Sciurba FC, et al. FEV1/FVC severity stages for chronic obstructive pulmonary disease. Am J Respir Crit Care Med . 2023;208:676–684. - PMC - PubMed
    1. Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. ERS Global Lung Function Initiative Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J . 2012;40:1324–1343. - PMC - PubMed
    1. Agustí A, Celli BR, Criner GJ, Halpin D, Anzueto A, Barnes P, et al. Global Initiative for Chronic Obstructive Lung Disease 2023 report: GOLD executive summary. Am J Respir Crit Care Med . 2023;207:819–837. - PMC - PubMed
    1. Stanojevic S, Kaminsky DA, Miller MR, Thompson B, Aliverti A, Barjaktarevic I, et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J . 2022;60:2101499. - PubMed
    1. Tejero E, Prats E, Casitas R, Galera R, Pardo P, Gavilán A, et al. Classification of airflow limitation based on z-score underestimates mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med . 2017;196:298–305. - PubMed