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Case Reports
. 2023 Nov 14:17:1287514.
doi: 10.3389/fnins.2023.1287514. eCollection 2023.

Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study

Sandra P Smieszek  1 , Alyssa R Kaden  1 , Caroline E Johnson  1 , Jennifer L Brzezynski  1 , Changfu Xiao  1 , Christos M Polymeropoulos  1 , Gunther Birznieks  1 , Helene A Emsellem  2   3 , Mihael H Polymeropoulos  1
Affiliations
Case Reports

Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study

Sandra P Smieszek et al. Front Neurosci. .

Erratum in

Abstract

We present a case of an adult female diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD) and Optic Nerve Hypoplasia (ONH), with a confirmed delayed Dim Light Melatonin Onset (DLMO), who reports the inability to fall asleep at their desired bedtime and obtain adequate sleep nightly, despite the ability to have a full night's sleep when not required to be up at a specific time for societal requirements. The participant was enrolled in an 11-month Open-Label Extension (OLE) following the randomized portion of a clinical study and was successfully treated with tasimelteon. DSWPD symptoms were resolved, and their previously delayed sleep-wake cycle was advanced.

Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT04652882, identifier NCT04652882.

Keywords: Delayed Sleep-Wake Phase Disorder; Optic Nerve Hypoplasia; biological rhythms; circadian rhythm disorders; clinical trials research; delayed sleep; night owl; sleep/wake mechanisms.

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Conflict of interest statement

All authors are employees of Vanda Pharmaceuticals Inc. This work was supported and funded by Vanda Pharmaceuticals Inc. SS, AK, CJ, JB, CX, CP, GB, and MP are all employees and stockholders of Vanda Pharmaceuticals Inc. HE is an Investigator in this clinical study.

Figures

FIGURE 1
FIGURE 1
Sleep onset during screening and Open-Label Extension (OLE). The sleep onset time was significantly improved during the OLE phase as compared to the screening phase (p < 0.0001).
FIGURE 2
FIGURE 2
Sleep diary data during screening and Open-Label Extension (OLE). Sleep timing (sleep onset, duration, and wake time) was measured by an electronic daily sleep diary over the entire study, screening (green) and OLE (yellow).
See this image and copyright information in PMC

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