Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 16:17:1274837.
doi: 10.3389/fnins.2023.1274837. eCollection 2023.

Electroencephalogram measured functional connectivity for delirium detection: a systematic review

Angelica Hanna  1   2 , Jeffrey Jirsch  1   3 , Claude Alain  4   5   6   7 , Sara Corvinelli  2   4 , Jacques S Lee  1   2   4
Affiliations
Review

Electroencephalogram measured functional connectivity for delirium detection: a systematic review

Angelica Hanna et al. Front Neurosci. .

Abstract

Objective: Delirium is an acute alteration of consciousness marked by confusion, inattention, and changes in cognition. Some speculate that delirium may be a disorder of functional connectivity, but the requirement to lay still may limit measurement with existing functional imaging modalities in this population. Electroencephalography (EEG) may allow for a more feasible approach to the study of potential connectivity disturbances in delirium. We conducted a systematic review to investigate whether there are EEG-measurable differences in brain functional connectivity in the resting state associated with delirium.

Methods: Medline, PubMed, PsychInfo, Embase and CINAHL were searched for relevant articles containing original data studying EEG functional connectivity measures in delirium.

Results: The search yielded 1,516 records. Following strict inclusion criteria, four studies were included in the review. The studies used a variety of EEG measures including phase lag index, coherence, entropy, shortest path length, minimum spanning tree, and network clustering coefficients to study functional connectivity between scalp electrodes. Across connectivity measures, delirium was associated with decreased brain functional connectivity. All four studies found decreased alpha band connectivity for patients with delirium. None of the studies directly compared the different motor subtypes of delirium.

Significance: This systematic review provides converging evidence for disturbances in oscillatory-based functional connectivity in delirium.

Keywords: EEG; delirium; electroencephalography; functional connectivity; review.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA diagram showing the article selection process from Ovid MEDLINE, Ovid Embase, CINAHL, and PsycINFO database searches.
See this image and copyright information in PMC

References

    1. Alain C., Ross B. (2008). “The role of neuroelectric and neuromagnetic recordings in assessing learning and rehabilitation effects” in Cognitive neurorehabilitation: evidence and application. eds. Stuss D. T., Winocur G., Robertson I. H.. 2nd ed (New York, NY: Cambridge University Press; ), 182–199.
    1. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. edn Washington, DC: American Psychiatric Association, p. 947
    1. Anderson A., Cohen M. S. (2013). Decreased small-world functional network connectivity and clustering across resting state networks in schizophrenia: an fMRI classification tutorial. Front. Hum. Neurosci. 7:520. doi: 10.3389/fnhum.2013.00520 - DOI - PMC - PubMed
    1. Axmacher N., Mormann F., Fernández G., Cohen M. X., Elger C. E., Fell J. (2007). Sustained neural activity patterns during working memory in the human medial temporal lobe. J. Neurosci. 27, 7807–7816. doi: 10.1523/JNEUROSCI.0962-07.2007, PMID: - DOI - PMC - PubMed
    1. Boord M. S., Davis D. H. J., Psaltis P. J., Coussens S. W., Feuerriegel D., Garrido M. I., et al. . (2021a). DelIrium VULnerability in GEriatrics (DIVULGE) study: a protocol for a prospective observational study of electroencephalogram associations with incident postoperative delirium. BMJ Neurol. Open 3:e000199. doi: 10.1136/bmjno-2021-000199, PMID: - DOI - PMC - PubMed

LinkOut - more resources