Reply to: How carvedilol does not activate β₂-adrenoceptors

Affiliations

¹ Molecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany. kostenis@uni-bonn.de.
² Molecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany.
³ Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University of Jena, 07747, Jena, Germany.
⁴ ISAR Bioscience, Semmelweisstraße 5, 82152, Planegg, Germany.
⁵ Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354, Esch-sur-Alzette, Luxembourg.
⁶ Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University of Jena, 07745, Jena, Germany.
⁷ Department of Pharmaceutical Chemistry, Philipps-University of Marburg, 35032, Marburg, Germany.
⁸ Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
⁹ InterAx Biotech AG, 5234, Villigen, Switzerland.
¹⁰ Ikherma Consulting Ltd, Hitchin, SG4 0TY, UK.
¹¹ Graduate School of Pharmaceutical Science, Tohoku University, Sendai, 980-8578, Japan.

Comment

Evi Kostenis et al. Nat Commun. 2023.

. 2023 Nov 30;14(1):7867.

doi: 10.1038/s41467-023-42849-4.

¹ Molecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany. kostenis@uni-bonn.de.
² Molecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, 53115, Bonn, Germany.
³ Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller-University of Jena, 07747, Jena, Germany.
⁴ ISAR Bioscience, Semmelweisstraße 5, 82152, Planegg, Germany.
⁵ Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354, Esch-sur-Alzette, Luxembourg.
⁶ Institute for Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University of Jena, 07745, Jena, Germany.
⁷ Department of Pharmaceutical Chemistry, Philipps-University of Marburg, 35032, Marburg, Germany.
⁸ Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
⁹ InterAx Biotech AG, 5234, Villigen, Switzerland.
¹⁰ Ikherma Consulting Ltd, Hitchin, SG4 0TY, UK.
¹¹ Graduate School of Pharmaceutical Science, Tohoku University, Sendai, 980-8578, Japan.

No abstract available

Conflict of interest statement

S.S. is the founder and scientific advisor of 7TM Antibodies GmbH, Jena, Germany. The remaining authors declare no competing interests.

How carvedilol does not activate β₂-adrenoceptors.
Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. Lefkowitz RJ, et al. Nat Commun. 2023 Nov 30;14(1):7866. doi: 10.1038/s41467-023-42848-5. Nat Commun. 2023. PMID: 38036531 Free PMC article. No abstract available.

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