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Meta-Analysis
. 2023 Dec 1;23(4):471-488.

Effect of Bushen Tiansui Decoction on Delayed Fracture Healing: A Systematic Review and Meta-analysis

Ling Cheng #  1 , Gao Wang #  2 , Hualong Lu  1 , Song Li  1 , Wei Xiong  1 , Jun Wang  3
Affiliations
Meta-Analysis

Effect of Bushen Tiansui Decoction on Delayed Fracture Healing: A Systematic Review and Meta-analysis

Ling Cheng et al. J Musculoskelet Neuronal Interact. .

Abstract

This review aimed to validate the therapeutic potential of Bushen Tiansui decoction (BSTSD), a traditional Chinese formulation, in treating delayed union of fractures. Comprehensive database searches identified randomized controlled trials up to September 13, 2022, assessing BSTSD's efficacy in delayed fracture healing. Outcomes were bone metabolism indexes and Harris hip scores. Quality and risk assessments were conducted using the Cochrane Collaboration's tools. Data were analyzed using RevMan software, with sensitivity analysis through Stata. BSTSD significantly improved bone GLA protein (SMD=1.76, P<0.00001) and alkaline phosphatase (SMD=1.31, P<0.00001). Additionally, Harris hip scores for pain, function, deformity, and motion showed marked improvement. BSTSD treatment also demonstrated enhanced clinical efficiency (RR=1.27, P<0.00001) with fewer complications. Sensitivity analyses indicated consistent results. BSTSD shows promise in treating delayed fracture unions, yet conclusions necessitate further high-quality research for validation.

Keywords: Bushen Tiansui Decoction; Chinese Medicine Compound; Delayed Fracture Healing; Meta-Analysis; Traditional Chinese Medicine Decoction.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the selection of studies.
Figure 2
Figure 2
The risk of bias graph of included studies.
Figure 3
Figure 3
Risk of bias summary of included studies.
Figure 4
Figure 4
Forest plot of BGP.
Figure 5
Figure 5
Forest plot of ALP.
Figure 6
Figure 6
Forest plot of Harris hip score (pain).
Figure 7
Figure 7
Forest plot of Harris hip score (function).
Figure 8
Figure 8
Forest plot of Harris hip score (deformity).
Figure 9
Figure 9
Forest plot of Harris hip score (range of motion).
Figure 10
Figure 10
Forest plot of clinical efficiency.
Figure 11
Figure 11
Forest plot of complication rate.
Figure 12
Figure 12
Funnel plot of clinical efficiency.
Figure S1
Figure S1
Risk of bias summary of included studies.
Figure S2
Figure S2
Sensitivity analysis of BGP.
Figure S3
Figure S3
Sensitivity analysis of ALP.
See this image and copyright information in PMC

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