The management of myelofibrosis: A British Society for Haematology Guideline

Donal P McLornan¹, Bethan Psaila^{2

3}, Joanne Ewing⁴, Andrew Innes⁵, Siamak Arami⁶, Jessica Brady⁷, Nauman M Butt⁸, Catherine Cargo⁹, Nicholas C P Cross¹⁰, Sebastian Francis¹¹, Rebecca Frewin¹², Mamta Garg¹³, Anna L Godfrey¹⁴, Anna Green¹⁵, Alesia Khan⁹, Steve Knapper¹⁶, Jonathan Lambert¹, Andrew McGregor¹⁷, Mary Frances McMullin¹⁸, Jyoti Nangalia¹⁹, Pratap Neelakantan²⁰, Claire Woodley²¹, Adam Mead^{2

3}, Tim C P Somervaille²², Claire N Harrison²¹; BSH Committee

Affiliations

¹ Department of Haematology, University College London Hospitals, London, UK.
² MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
³ Department of Haematology, Churchill Hospital, Oxford University NHS Trust, Oxford, UK.
⁴ Department of Haematology, University Hospitals Birmingham Trust, London, UK.
⁵ Department of Haematology, Imperial College, London, UK.
⁶ Department of Haematology, London Northwest Healthcare University NHS Trust, London, UK.
⁷ Department of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
⁸ Department of Haematology, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
⁹ Department of Haematology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, UK.
¹⁰ Faculty of Medicine, University of Southampton, Southampton, UK.
¹¹ Department of Haematology, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK.
¹² Department of Haematology, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK.
¹³ Department of Haematology, University Hospitals Leicester NHS Trust, Leicester, UK.
¹⁴ Haematopathology & Oncology Diagnostics Service, Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
¹⁵ Department of Histopathology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
¹⁶ Department of Haematology, Cardiff University, Cardiff, UK.
¹⁷ Department of Haematology, Freeman Hospital, Newcastle, UK.
¹⁸ Centre for Medical Education, Queen's University, Belfast, UK.
¹⁹ Wellcome Sanger Institute, University of Cambridge, Cambridge, UK.
²⁰ Department of Haematology, Royal Berkshire NHS Foundation Trust, London, UK.
²¹ Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
²² Cancer Research UK Manchester Institute & The Christie NHS Foundation Trust, Manchester, UK.

PMID: 38037886
DOI: 10.1111/bjh.19186

The management of myelofibrosis: A British Society for Haematology Guideline

Donal P McLornan et al. Br J Haematol. 2024 Jan.

. 2024 Jan;204(1):136-150.

doi: 10.1111/bjh.19186. Epub 2023 Dec 1.

Authors

Affiliations

¹ Department of Haematology, University College London Hospitals, London, UK.
² MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
³ Department of Haematology, Churchill Hospital, Oxford University NHS Trust, Oxford, UK.
⁴ Department of Haematology, University Hospitals Birmingham Trust, London, UK.
⁵ Department of Haematology, Imperial College, London, UK.
⁶ Department of Haematology, London Northwest Healthcare University NHS Trust, London, UK.
⁷ Department of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
⁸ Department of Haematology, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK.
⁹ Department of Haematology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, UK.
¹⁰ Faculty of Medicine, University of Southampton, Southampton, UK.
¹¹ Department of Haematology, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK.
¹² Department of Haematology, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK.
¹³ Department of Haematology, University Hospitals Leicester NHS Trust, Leicester, UK.
¹⁴ Haematopathology & Oncology Diagnostics Service, Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
¹⁵ Department of Histopathology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
¹⁶ Department of Haematology, Cardiff University, Cardiff, UK.
¹⁷ Department of Haematology, Freeman Hospital, Newcastle, UK.
¹⁸ Centre for Medical Education, Queen's University, Belfast, UK.
¹⁹ Wellcome Sanger Institute, University of Cambridge, Cambridge, UK.
²⁰ Department of Haematology, Royal Berkshire NHS Foundation Trust, London, UK.
²¹ Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
²² Cancer Research UK Manchester Institute & The Christie NHS Foundation Trust, Manchester, UK.

PMID: 38037886
DOI: 10.1111/bjh.19186

No abstract available

Keywords: JAK; management; myelofibrosis; transplantation.

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Comment in

Evidence creation for myelofibrosis: Challenges and opportunities.
Gupta V. Gupta V. Br J Haematol. 2024 Jan;204(1):19-21. doi: 10.1111/bjh.19257. Epub 2023 Dec 11. Br J Haematol. 2024. PMID: 38083995

References

REFERENCES

1. Reilly JT, McMullin MF, Beer PA, Butt N, Conneally E, Duncombe AS, et al. Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and management of myelofibrosis 2012. Br J Haematol. 2014;167(3):418-420.
1. Titmarsh GJ, Duncombe AS, McMullin MF, O'Rorke M, Mesa R, De Vocht F, et al. How common are myeloproliferative neoplasms? A systematic review and meta-analysis. Am J Hematol. 2014;89(6):581-587.
1. Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366(9):799-807.
1. Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366(9):787-798.
1. Verstovsek S, Kiladjian J, Vannucchi AM, Mesa RA, Squier P, Hamer-Maansson JE, et al. Early intervention in myelofibrosis and impact on outcomes: a pooled analysis of the COMFORT-I and COMFORT-II studies. Cancer. 2023;129:1681-1690.

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The management of myelofibrosis: A British Society for Haematology Guideline

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The management of myelofibrosis: A British Society for Haematology Guideline

Authors

Affiliations

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References

REFERENCES

MeSH terms

Grants and funding

LinkOut - more resources

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