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Review
. 2024;21(8):1014-1020.
doi: 10.2174/0115701794265887231014061317.

Anti-inflammatory and Antimicrobial Potential of 1, 3, 4-oxadiazoles and its Derivatives: A Review

Tarun Chaudhary  1 , Prabhat Kumar Upadhyay  1 , Ritu Kataria  2
Affiliations
Review

Anti-inflammatory and Antimicrobial Potential of 1, 3, 4-oxadiazoles and its Derivatives: A Review

Tarun Chaudhary et al. Curr Org Synth. 2024.

Abstract

1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial property. Their precise mechanism of action is not known but it is postulated that they act by inhibiting the biosynthesis of certain prostaglandins. 1, 3, 4-oxadiazoles are a class of heterocyclic compounds with wide variety of biological and pharmacological activities. They have been reported to possess analgesic, antimicrobial, antipyretic and anti-inflammatory properties. These compounds are also active against a number of other inflammatory conditions such as arthritis, gout etc. A wide variety of these compounds have been synthesized and some of them are under clinical trials. In this review article, anti-inflammatory and antimicrobial activity of the 1, 3, 4- oxadiazole shall be discussed.

Keywords: 1; 3; 4-oxadiazole; Oxadiazole derivatives; anti-inflammatory; antimicrobial.; heterocyclic compounds; inflammation.

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References

    1. Chow Y.Y.; Chin K.Y.; The role of inflammation in the pathogenesis of osteoarthritis. Mediators Inflamm 2020,2020,1-19 - DOI - PubMed
    1. Moo C.L.; Yang S.K.; Yusoff K.; Ajat M.; Thomas W.; Abushelaibi A.; Lim S.H.E.; Lai K.S.; Mechanisms of antimicrobial resistance (AMR) and alternative approaches to overcome AMR. Curr Drug Discov Technol 2020,17(4),430-447 - DOI - PubMed
    1. Marston H.D.; Dixon D.M.; Knisely J.M.; Palmore T.N.; Fauci A.S.; Antimicrobial resistance. JAMA 2016,316(11),1193-1204 - DOI - PubMed
    1. Srivastava J.; Chandra H.; Nautiyal A. R.; Kalra S. J.; Antimicrobial resistance (AMR) and plant-derived antimicrobials (PDAms) as an alternative drug line to control infections. 3 Biotech 2014,4(5),451-460
    1. Michael C.A.; Dominey-Howes D.; Labbate M.; The antimicrobial resistance crisis: causes, consequences, and management. Front Public Health 2014,2,145 - DOI - PubMed

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