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Review
. 2024 Jul;61(7):3882-3898.
doi: 10.1007/s12035-023-03728-7. Epub 2023 Dec 1.

The Role of Necroptosis in Cerebral Ischemic Stroke

Qingsong Wang #  1 , Fan Yang #  1 , Kun Duo  1 , Yue Liu  1 , Jianqiang Yu  1 , Qihui Wu  2 , Zhenyu Cai  3   4
Affiliations
Review

The Role of Necroptosis in Cerebral Ischemic Stroke

Qingsong Wang et al. Mol Neurobiol. 2024 Jul.

Abstract

Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes and is the leading cause of disability worldwide. Due to disrupted blood supply to the brain, cerebral ischemic injury is trigged by a series of complex pathophysiological events including excitotoxicity, oxidative stress, inflammation, and cell death. Currently, there are few treatments for cerebral ischemia owing to an incomplete understanding of the molecular and cellular mechanisms. Accumulated evidence indicates that various types of programmed cell death contribute to cerebral ischemic injury, including apoptosis, ferroptosis, pyroptosis and necroptosis. Among these, necroptosis is morphologically similar to necrosis and is mediated by receptor-interacting serine/threonine protein kinase-1 and -3 and mixed lineage kinase domain-like protein. Necroptosis inhibitors have been shown to exert inhibitory effects on cerebral ischemic injury and neuroinflammation. In this review, we will discuss the current research progress regarding necroptosis in cerebral ischemia as well as the application of necroptosis inhibitors for potential therapeutic intervention in ischemic stroke.

Keywords: Cerebral ischemia; MLKL; Necroptosis; RIPK1; RIPK3.

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