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Review
. 2024 Jan-Mar;46(1):85-92.
doi: 10.1590/2175-8239-JBN-2023-0065en.

Trimethylamine N-oxide and kidney diseases: what do we know?

[Article in English, Portuguese]
Ozkan Gungor  1 , Nuri Baris Hasbal  2 , Demet Alaygut  3
Affiliations
Review

Trimethylamine N-oxide and kidney diseases: what do we know?

[Article in English, Portuguese]
Ozkan Gungor et al. J Bras Nefrol. 2024 Jan-Mar.

Abstract
in English, Portuguese

In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body. When dysbiosis of intestinal microbial homeostasis occurs, pathogenic metabolites may increase and one of them is trimethyl amine-N-oxide (TMAO). TMAO is thought to have a role in the pathogenesis of insulin resistance, diabetes, hyperlipidemia, atherosclerotic heart diseases, and cerebrovascular events. TMAO level is also associated with renal inflammation, fibrosis, acute kidney injury, diabetic kidney disease, and chronic kidney disease. In this review, the effect of TMAO on various kidney diseases is discussed.

No intestino humano, existe um microbioma metabolicamente ativo cujos produtos metabólicos alcançam diversos órgãos e são utilizados nas atividades fisiológicas do corpo. Quando ocorre disbiose da homeostase microbiana intestinal, os metabólitos patogênicos podem aumentar, e um deles é o N-óxido de trimetilamina (TMAO). Acredita-se que o TMAO tenha um papel na patogênese da resistência à insulina, diabetes, hiperlipidemia, doenças cardíacas ateroscleróticas e eventos cerebrovasculares. O nível de TMAO também está associado à inflamação renal, fibrose, lesão renal aguda, doença renal diabética e doença renal crônica. Nesta revisão, discute-se o efeito do TMAO em diversas doenças renais.

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Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

Figures

Figure 1.
Figure 1.. TMAO and its associations with various diseases.
Figure 2.
Figure 2.. Relationship between TMAO and hypertension.
See this image and copyright information in PMC

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