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Comment
. 2024 Mar;20(3):2282-2284.
doi: 10.1002/alz.13550. Epub 2023 Dec 2.

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

Julie Le Borgne  1 ; EADB, GR@ACE, Degesco, EADI, GERAD, DemGene; Philippe Amouyel  1 , Ole Andreassen  2 , Ruth Frikke-Schmidt  3   4 , Mikko Hiltunen  5 , Martin Ingelsson  6   7   8 , Alfredo Ramirez  9   10   11   12   13 , Giacomina Rossi  14 , Agustin Ruiz  15   16 , Pascual Sanchez-Juan  16   17 , Rebecca Sims  18 , Kristel Sleegers  19   20 , Magda Tsolaki  21   22 , Sven J van der Lee  23   24   25 , Julie Williams  18   26 , Jean-Charles Lambert  1 , Céline Bellenguez  1
Affiliations
Comment

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

Julie Le Borgne et al. Alzheimers Dement. 2024 Mar.
No abstract available

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Conflict of interest statement

Martin Ingelsson is a paid consultant to BioArtic.

Figures

FIGURE 1
FIGURE 1
Results of rs12775171 association with Alzheimer's disease (AD) risk in apolipoprotein E (APOE) ε4‐ women and the other sex‐APOEε4 subsets compared with the effect reported in the Alzheimer's Disease Genetics Consortium (ADGC) APOEε4‐ women from Chung et al. 2022. The effect allele is G with a frequency of 0.06 in all models. The black square whose size is proportional to the sample size represents the odds ratio (OR) and the blue line the confidence interval (CI). Interaction P are p‐values of the heterogeneity test between the different group pairs (1 degree of freedom test) using the APOEε4‐ women group as a reference for each test (supporting information). EA, Effect allele; P, p‐value.
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References

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