Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 14;9(11):e22330.
doi: 10.1016/j.heliyon.2023.e22330. eCollection 2023 Nov.

Ferulated Poly(vinyl alcohol) based hydrogels

Simone Pepi  1 , Marco Paolino  1 , Mario Saletti  1 , Jacopo Venditti  1 , Luigi Talarico  1 , Marco Andreassi  1 , Germano Giuliani  1 , Gianfranco Caselli  2 , Roberto Artusi  2 , Andrea Cappelli  1 , Gemma Leone  1   3 , Agnese Magnani  1   3 , Lucio Rovati  2
Affiliations

Ferulated Poly(vinyl alcohol) based hydrogels

Simone Pepi et al. Heliyon. .

Abstract

New graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capability of FA, formed in water strong gels as verified by rheological analyses. The resulting hydrogels were characterized to evaluate their applicability as wound dressing. In this perspective, their capability to absorb and retain a large amount of fluid without dissolving was verified by swelling kinetics and Moisture Vapour Transmission Rate measurements. Their stability towards mechanical solicitations was assessed by quantifying elasticity, compliance, stress-relaxation, and adhesivity properties. The analyses pointed out that hydrogel PVA-FA2-3 obtained by feruloylation of PVA with bis-imidazole derivative of ferulic acid using an acylation agent/polymer molar ratio 0.03/1 resulted the best candidate for the foreseen application.

Keywords: Ferulic acid; Hydrogel; Rheology; Wound dressing; poly(vinyl alcohol) (PVA).

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Scheme 1
Scheme 1
Esterification of PVA by using FA N-acylimidazole derivatives 1 or 2.
Fig. 1
Fig. 1
A: IR spectra of native PVA polymer and PVA-FA copolymers at dry state; B: Comparison between IR spectra of native PVA and PVA-FA1-5 (*: crystallinity band 1142 cm−1 [31]).
Fig. 2
Fig. 2
Comparison of 1H NMR spectra obtained with PVA-FA1-2.5 derivative (DMSO‑d6, 400 MHz) in the absence (trace 2 from the bottom), or in the presence of increasing amounts (traces 3–5 from the bottom) of free FA (added as a solution in DMSO‑d6) with that obtained with pure FA (bottom trace).
Fig. 3
Fig. 3
Swelling kinetics of PVA-FA hydrogels.
Fig. 4
Fig. 4
Thermograms of PVA polymer and PVA-FA hydrogels obtained plotting weight (%) and weight derivative (%/°C) versus temperature.
Fig. 5
Fig. 5
DSC thermographs melting profiles of PVA-FA derivatives.
Fig. 6
Fig. 6
A: Gꞌ and Gꞌꞌ trends as a function of frequency; B: Eꞌ and Eꞌꞌ trends as a function of frequency; C: compliance trends; D: tan delta trends as a function of frequency.
Fig. 7
Fig. 7
Adhesive behaviour of PVA-FA hydrogels.
See this image and copyright information in PMC

References

    1. Tang Y., Lan X., Liang C., Zhong Z., Xie R., Zhou Y., Miao X., Wang H., Wang W. Honey loaded alginate/PVA nanofibrous membrane as potential bioactive wound dressing. Carbohydr. Polym. 2019;219:113–120. - PubMed
    1. Arun Karthick S., Manjari K., Gundhavi Devi M. Biocompatible and bioactive PVA/Sericin/Chitosan nanofibrous wound dressing matrix. Appl. Surf. Sci. Adv. 2023;13
    1. Li Z., Milionis A., Zheng Y., Yee M., Codispoti L., Tan F., Yap C.H. Superhydrophobic hemostatic nanofiber composites for fast clotting and minimal adhesion. Nat. Commun. 2019;10:5562. - PMC - PubMed
    1. Nie L., Wei Q., Sun M., Ding P., Wang L., Sun Y., Ding X., Okoro O.V., Jiang G., Shavandi A. Injectable, self-healing, transparent, and antibacterial hydrogels based on chitosan and dextran for wound dressings. Int. J. Biol. Macromol. 2023;233 - PubMed
    1. Sadeghi-Aghbash M., Rahimnejad M., Adeli H., Feizi F. Fabrication and development of PVA/Alginate nanofibrous mats containing Arnebia Euchroma extract as a burn wound dressing. React. Funct. Polym. 2022;181

LinkOut - more resources