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. 1979 Mar;15(3):478-80.
doi: 10.1128/AAC.15.3.478.

Effect of a Salmonella group H1 R factor on virulence and response of infections to antimicrobial therapy

T Butler, C W Shuster, A Franco

Effect of a Salmonella group H1 R factor on virulence and response of infections to antimicrobial therapy

T Butler et al. Antimicrob Agents Chemother. 1979 Mar.

Abstract

A group H1 R factor encoding resistance to chloramphenicol, streptomycin, sulfonamide, and tetracycline was transferred into Salmonella typhimurium LT-2. The virulence of LT-2 for mice, as assessed by intraperitoneal 50% lethal dose and the number of organisms in the spleen, was not affected by the R factor. On the other hand, the R factor conferred resistance in mouse infections to therapy with chloramphenicol and trimethoprim plus sulfamethoxazole.

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References

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