Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 10:5:100191.
doi: 10.1016/j.cccb.2023.100191. eCollection 2023.

Measurement of resistance-area product by transcranial Doppler: An alternative tool for cognitive screening in hypertensive on drug treatment?

Michel Ferreira Machado  1 , Henrique Cotchi Simbo Muela  2 , Valeria Aparecida Costa-Hong  2 , Ronney B Panerai  3 , Monica S Yassuda  4 , Natalia Cristina Moraes  1 , Claudia Maia Memória  1 , Edson Bor-Seng-Shu  1 , Ricardo Nitrini  1 , Luiz Aparecido Bortolotto  2 , Ricardo de Carvalho Nogueira  1
Affiliations

Measurement of resistance-area product by transcranial Doppler: An alternative tool for cognitive screening in hypertensive on drug treatment?

Michel Ferreira Machado et al. Cereb Circ Cogn Behav. .

Abstract

Introduction: Arterial hypertrophy and remodeling are adaptive responses present in systemic arterial hypertension that can result in silent ischemia and neurodegeneration, compromising brain connections and cognitive performance (CP). However, CP is affected differently over time, so traditional screening methods may become less sensitive in assessing certain cognitive domains. The study aimed to evaluate whether cerebrovascular hemodynamic parameters can serve as a tool for cognitive screening in hypertensive without clinically manifest cognitive decline.

Methods: Participants were allocated into groups: non-hypertensive (n = 30) [group 1], hypertensive with systolic blood pressure (SBP) < 140 and diastolic blood pressure (DBP) < 90 mmHg (n = 54) [group 2] and hypertensive with SBP ≥ 140 or DBP ≥ 90 (n = 31) [group 3]. Measurements of blood pressure and middle cerebral artery blood flow velocity were obtained from digital plethysmography and transcranial Doppler. For the cognitive assessment, the Mini Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) and a broad neuropsychological battery were applied.

Results: Patients in groups 2 and 3 show no significant differences in most of the clinical-epidemiological variables or pulsatility index (p = 0.361), however compared to group 1 and 2, patients in group 3 had greater resistance-area product [RAP] (1.7 [±0.7] vs. 1.2 [±0.2], p < 0.001). There was a negative correlation between RAP, episodic memory (r = -0.277, p = 0.004) and cognitive processing speed (r = -0.319, p = 0.001).

Conclusion: RAP reflects the real cerebrovascular resistance, regardless of the direct action of antihypertensive on the microcirculation, and seems to be a potential alternative tool for cognitive screening in hypertensive.

Keywords: Arterial stiffness; Cerebral blood flow; Cognitive decline; Hypertension; Ultrasonography Doppler.

PubMed Disclaimer

Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Enrollment of patients.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Editorial. CCCB: The journal at age 5.
    Hainsworth AH, Paracampo R, Wallin A. Hainsworth AH, et al. Cereb Circ Cogn Behav. 2024 Sep 7;7:100368. doi: 10.1016/j.cccb.2024.100368. eCollection 2024. Cereb Circ Cogn Behav. 2024. PMID: 39737420 Free PMC article.

References

    1. Khan U., Porteous L., Hassan A., Markus H.S. Risk factor profile of cerebral small vessel disease and its subtypes. J. Neurol. Neurosurg. Psyshiatry. 2007;78:702–706. - PMC - PubMed
    1. Claassen J.A., Meel-van den Abeelen A.S.S., Simpson D.M., Panerai R.B., international Cerebral Autoregulation Research Network (CARNet) Transfer function analysis of dynamic cerebral autoregulation: a white paper from the international cerebral autoregulation research network. J. Cereb. Blood Flow Metab. 2016;36:665–680. - PMC - PubMed
    1. Levi-Marpillat N., Macquin-Mavier I., Tropeano A.I., Bachoud-Levi A.C., Maison P. Anihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. J. Hypertens. 2013;31:1073–1082. - PubMed
    1. Nobili F., Rodriguez G., Marenco S., de Carli F., Gambaro M., Castello C., et al. Regional cerebral blood flow in chronic hypertension. Stroke. 1993;24:1148–1153. - PubMed
    1. Markus H.S. Genes, endothelial function and cerebral small vessel disease in man. Exp. Physiol. 2008;93:121–127. - PubMed

LinkOut - more resources