Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Apr;15(4):630-2.
doi: 10.1128/AAC.15.4.630.

Effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against Serratia marcescens

T Sirisanthana, S A Lerner

Effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against Serratia marcescens

T Sirisanthana et al. Antimicrob Agents Chemother. 1979 Apr.

Abstract

Clavulanic acid, a potent beta-lactamase inhibitor, reduced the minimum inhibitory concentrations of carbenicillin for 13 of 15 clinical isolates of Serratia marcescens by at least eightfold. The combination of clavulanic acid and carbenicillin also exhibited synergistic activity with gentamicin against 11 of 15 isolates tested, including 9 of 10 strains which were highly resistant to carbenicillin (minimum inhibitory concentration >/= 8,000 mug/ml) and had previously been found resistant to the synergistic activity between carbenicillin and gentamicin.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1978 Mar;13(3):389-93 - PubMed
    1. Antimicrob Agents Chemother. 1978 May;13(5):813-9 - PubMed
    1. Am J Clin Pathol. 1976 Jul;66(1):96-100 - PubMed
    1. Antimicrob Agents Chemother. 1976 Dec;10(6):878-84 - PubMed
    1. Antimicrob Agents Chemother. 1977 May;11(5):852-7 - PubMed

MeSH terms

LinkOut - more resources