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Review
. 2023 Nov 15:14:1284410.
doi: 10.3389/fphys.2023.1284410. eCollection 2023.

Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Ines Martic #  1   2 , Federica Papaccio #  3 , Barbara Bellei #  3 , Maria Cavinato #  1   2
Affiliations
Review

Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Ines Martic et al. Front Physiol. .

Abstract

Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy production and free radical maintenance. However, mitochondrial metabolism as well as processes of mitochondrial dynamics, biogenesis, and degradation varies considerably among the different types of cells that populate the skin. Disturbed mitochondrial function is known to promote aging and inflammation of the skin, leading to impairment of physiological skin function and the onset of skin pathologies. In this review, we discuss the essential role of mitochondria in different skin cell types and how impairment of mitochondrial morphology, physiology, and metabolism in each of these cellular compartments of the skin contributes to the process of skin aging.

Keywords: aging; mitochondria; skin; skin cells; skin homeostasis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Overview of skin structure and cellular composition.
FIGURE 2
FIGURE 2
Mitochondrial structure, function, and aging-related changes.
FIGURE 3
FIGURE 3
Mitochondrial Dysfunctions and Cellular Consequences in Aging Skin Cells. Comprehensive overview of mitochondrial dysfunctions observed in various skin cell types during the aging process, elucidating their subsequent implications for skin health.
See this image and copyright information in PMC

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