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Review
. 2024 Feb;46(2):e2300184.
doi: 10.1002/bies.202300184. Epub 2023 Dec 4.

Telomeres cooperate with the nuclear envelope to maintain genome stability

Rekha Rai  1 , Tori Sodeinde  1   2 , Ava Boston  1   2 , Sandy Chang  1   3   4
Affiliations
Review

Telomeres cooperate with the nuclear envelope to maintain genome stability

Rekha Rai et al. Bioessays. 2024 Feb.

Abstract

Mammalian telomeres have evolved safeguards to prevent their recognition as DNA double-stranded breaks by suppressing the activation of various DNA sensing and repair proteins. We have shown that the telomere-binding proteins TRF2 and RAP1 cooperate to prevent telomeres from undergoing aberrant homology-directed recombination by mediating t-loop protection. Our recent findings also suggest that mammalian telomere-binding proteins interact with the nuclear envelope to maintain chromosome stability. RAP1 interacts with nuclear lamins through KU70/KU80, and disruption of RAP1 and TRF2 function result in nuclear envelope rupture, promoting telomere-telomere recombination to form structures termed ultrabright telomeres. In this review, we discuss the importance of the interactions between shelterin components and the nuclear envelope to maintain telomere homeostasis and genome stability.

Keywords: DNA damage; genome stability; nuclear envelope; telomerase; telomere; telomere binding proteins.

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References

REFERENCES

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