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. 2023 Nov 30;389(22):2105-2107.
doi: 10.1056/NEJMc2307574.

Pre-Covid-19, SARS-CoV-2-Negative Multisystem Inflammatory Syndrome in Children

Sarah Benezech  1 , Liliane Khoryati  1 , Jade Cognard  1 , Stejara A Netea  2 , Taushif Khan  3 , Marion Moreews  1 , Kahina Saker  4 , Jean-Marie De Guillebon  5 , Samira Khaldi-Plassart  4 , Rémi Pescarmona  4 , Sebastien Viel  4 , Christophe Malcus  4 , Magali Perret  1 , Meriadeg Ar Gouilh  6 , Astrid Vabret  7 , Fabienne Venet  4 , Solenn Remy  4 , Emilie Chopin  4 , Gérard Lina  4 , François Vandenesch  1 , Noëmi Rousseaux  1 , Paul Bastard  8 , Shen-Ying Zhang  9 , Jean-Laurent Casanova  9 , Sophie Trouillet-Assant  4 , Thierry Walzer  1 , Taco W Kuijpers  2 , Etienne Javouhey  4 , Olivier Dauwalder  4 , Nico Marr  10 , Alexandre Belot  11
Affiliations

Pre-Covid-19, SARS-CoV-2-Negative Multisystem Inflammatory Syndrome in Children

Sarah Benezech et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Clinical and Biologic Features in SARS-CoV-2–Related Multisystem Inflammatory Syndrome in Children (MIS-C), non–SARS-CoV-2 MIS-C (nsMIS-C), and Kawasaki’s Disease (KD).
A heat map, shown in Panel A, shows the expression pattern of T-cell receptor Vβ chains on CD3+ T cells, as measured by flow cytometry after lineage and Vβ-chain staining of whole-blood or peripheral-blood mononuclear cells from patients in the following disease groups: MIS-C (Patients MIS-C1 through MIS-C22), nsMIS-C (Patients nsMIS-C1 through nsMIS-C6), KD (Patients KD 1 through KD 13), and KD shock syndrome (Patients KDSS 14 and KDSS 15). Levels of expression are shown as the standard deviation (SD) from the age-dependent reference mean value for each Vβ subset. Timelines of the clinical course in patients with nsMIS-C are shown in Panel B. A heat map of relative frequencies of symptoms and treatments that were administered is shown within each disease group in Panel C. The color key on the right indicates the proportion of the patients who had the symptom or had undergone the treatment. Panel D shows flow cytometric analyses of CD38, PD-1, and TIM-3 in the CD4+ T cells. Representative plots are shown for the following patients: MIS-C9, nsMIS-C5, and KDSS 14. Numbers in the contour plots represent the percentage of cells in the gated subset. IVIG denotes intravenous immune globulin, NA not available, PICU pediatric intensive care unit, and SARS-CoV-2 severe acute respiratory syndrome coronavirus 2.
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References

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