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Review
. 2023 Dec 5;196(1):10.
doi: 10.1007/s10661-023-12184-8.

Urinary dialkylphosphate metabolites in the assessment of exposure to organophosphate pesticides: from 2000 to 2022

Ana Paula Neves  1   2 , Ana Cristina Simões Rosa  3 , Ariane Leites Larentis  3 , Priscila Jeronimo da Silva Rodrigues Vidal  4 , Eline Simões Gonçalves  5 , Gabriel Rodrigues da Silveira  4 , Marcus Vinicius Corrêa Dos Santos  4 , Leandro Vargas Barreto de Carvalho  3 , Sergio Rabello Alves  3   6
Affiliations
Review

Urinary dialkylphosphate metabolites in the assessment of exposure to organophosphate pesticides: from 2000 to 2022

Ana Paula Neves et al. Environ Monit Assess. .

Abstract

The general population and workers are exposed to organophosphate insecticides, one of the leading chemical classes of pesticides used in rural and urban areas, in the control of arboviruses and agriculture. These pesticides cause environmental/occupational exposure and associated risks to human and environmental health. The objective of this study was to carry out an integrative review of epidemiological studies that identified and quantified dialkylphosphate metabolites in the urine of exposed populations, focusing on the vector control workers, discussing the application and the results found. Searches utilized the Pubmed, Scielo, and the Brazilian Digital Library of Theses and Dissertations (BDTD) databases between 2000 and 2021. From the 194 selected studies, 75 (39%) were with children/adolescents, 48 (24%) with rural workers, 36 (19%) with the general population, 27 (14%) with pregnant women, and 9 (4%) with vector control workers. The total dialkylphosphate concentrations found in the occupationally exposed population were higher than in the general population. Studies demonstrate that dialkylphosphates are sensitive and representative exposure biomarkers for environmental and occupational organophosphate exposure. The work revealed a lack of studies with vector control workers and a lack of studies in developing countries.

Keywords: Biomarkers; Organophosphate; Pesticides; Urine; Workers.

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