Pharmacological management of narcolepsy in children and adolescents

Giuseppe Plazzi^{1

2}, Fabio Pizza^{1

3}, Michel Lecendreux^{4

5}, Paul Gringras⁶, Lucie Barateau^{7

8}, Oliviero Bruni⁹, Patricia Franco^{10

11}, Alex Iranzo¹², Poul Jennum¹³, Ramin Khatami^{14

15}, Stine Knudsen-Heier^{16

17}, Silvia Miano¹⁸, Lino Nobili^{19

20}, Markku Partinen^{21

22}, Paul Reading²³, Karel Sonka²⁴, Attila Szakacs^{25

26}, Massimo Zenti^{27

28}, Ulf Kallweit^{29

30}, Gert J Lammers^{31

32}, Yves Dauvilliers^{7

8}, Claudio L A Bassetti^{33

34}

Affiliations

¹ IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
² University of Modena and Reggio Emilia, Modena, Italy.
³ Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
⁴ Pediatric Sleep Disorders Center, AP-HP, Robert Debre Hospital, Paris, France.
⁵ National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Paris, France.
⁶ Children's Sleep Medicine Kings College, London, UK.
⁷ National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France.
⁸ Institute of Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France.
⁹ Department of Developmental and Social Psychology, Sapienza University, Rome, Italy.
¹⁰ Pediatric Sleep Unit and National Reference Center for Narcolepsy, Mother-Children's Hospital, Hospices Civils de Lyon & U1028, Lyon Neuroscience Research Center (CRNL), University Lyon 1, Lyon, France.
¹¹ National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome Lyon, Lyon, France.
¹² Neurology Service, Sleep Disorders Centre, Hospital Clínic Barcelona, Universitat de Barcelona. IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
¹³ Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen, Denmark.
¹⁴ Center for Sleep Medicine, Sleep Research and Epileptology, Clinic Barmelweid AG, Barmelweid, Switzerland.
¹⁵ Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
¹⁶ Norwegian Center for Neurodevelopmental Disorders and Hypersomnias - NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway.
¹⁷ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹⁸ Neurocenter of Southern Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Sleep Medicine Unit, Civic Hospital, Lugano, Switzerland.
¹⁹ Child Neuropsychiatry Unit, IRCCS Istituto G. Gaslini, Genoa, Italy.
²⁰ Department of Neuroscience - Rehabilitation - Ophthalmology - Genetics - Child and Maternal Health (DINOGMI), University of Genova, Genoa, Italy.
²¹ Department of Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland.
²² Helsinki Sleep Clinic, Terveystalo Healthcare, Helsinki, Finland.
²³ Department of Neurology, The James Cook University Hospital, Middlesbrough, UK.
²⁴ Department of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
²⁵ Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁶ Department of Pediatrics, Halmstad County Hospital, Halmstad, Sweden.
²⁷ Associazione Italiana Narcolettici e Ipersonni, Florence, Italy.
²⁸ European Narcolepsy Alliance for Patients, Bruxells, Belgium.
²⁹ Center for Narcolepsy and Hypersomnias, Professorship for Narcolepsy and Hypersomnolence Research, Department of Medicine, University Witten/Herdecke, Witten, Germany.
³⁰ Center for Biomedical Education and Research (ZBAF), University Witten/Herdecke, Witten, Germany.
³¹ Stichting Epilepsie Instellingen Nederland (SEIN), Sleep-Wake Center, Heemstede, Netherlands.
³² Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands.
³³ Medical Faculty, University of Bern, Bern, Switzerland.
³⁴ Department of Neurology, University Hospital (Inselspital), Bern, Switzerland.

PMID: 38050449
DOI: 10.1111/jsr.14055

Pharmacological management of narcolepsy in children and adolescents

Giuseppe Plazzi et al. J Sleep Res. 2024 Aug.

. 2024 Aug;33(4):e14055.

doi: 10.1111/jsr.14055. Epub 2023 Dec 4.

Authors

Affiliations

¹ IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
² University of Modena and Reggio Emilia, Modena, Italy.
³ Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
⁴ Pediatric Sleep Disorders Center, AP-HP, Robert Debre Hospital, Paris, France.
⁵ National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome, Paris, France.
⁶ Children's Sleep Medicine Kings College, London, UK.
⁷ National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France.
⁸ Institute of Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France.
⁹ Department of Developmental and Social Psychology, Sapienza University, Rome, Italy.
¹⁰ Pediatric Sleep Unit and National Reference Center for Narcolepsy, Mother-Children's Hospital, Hospices Civils de Lyon & U1028, Lyon Neuroscience Research Center (CRNL), University Lyon 1, Lyon, France.
¹¹ National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome Lyon, Lyon, France.
¹² Neurology Service, Sleep Disorders Centre, Hospital Clínic Barcelona, Universitat de Barcelona. IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
¹³ Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Copenhagen, Denmark.
¹⁴ Center for Sleep Medicine, Sleep Research and Epileptology, Clinic Barmelweid AG, Barmelweid, Switzerland.
¹⁵ Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
¹⁶ Norwegian Center for Neurodevelopmental Disorders and Hypersomnias - NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway.
¹⁷ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹⁸ Neurocenter of Southern Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Sleep Medicine Unit, Civic Hospital, Lugano, Switzerland.
¹⁹ Child Neuropsychiatry Unit, IRCCS Istituto G. Gaslini, Genoa, Italy.
²⁰ Department of Neuroscience - Rehabilitation - Ophthalmology - Genetics - Child and Maternal Health (DINOGMI), University of Genova, Genoa, Italy.
²¹ Department of Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland.
²² Helsinki Sleep Clinic, Terveystalo Healthcare, Helsinki, Finland.
²³ Department of Neurology, The James Cook University Hospital, Middlesbrough, UK.
²⁴ Department of Neurology and Center for Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
²⁵ Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁶ Department of Pediatrics, Halmstad County Hospital, Halmstad, Sweden.
²⁷ Associazione Italiana Narcolettici e Ipersonni, Florence, Italy.
²⁸ European Narcolepsy Alliance for Patients, Bruxells, Belgium.
²⁹ Center for Narcolepsy and Hypersomnias, Professorship for Narcolepsy and Hypersomnolence Research, Department of Medicine, University Witten/Herdecke, Witten, Germany.
³⁰ Center for Biomedical Education and Research (ZBAF), University Witten/Herdecke, Witten, Germany.
³¹ Stichting Epilepsie Instellingen Nederland (SEIN), Sleep-Wake Center, Heemstede, Netherlands.
³² Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands.
³³ Medical Faculty, University of Bern, Bern, Switzerland.
³⁴ Department of Neurology, University Hospital (Inselspital), Bern, Switzerland.

PMID: 38050449
DOI: 10.1111/jsr.14055

No abstract available

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References

REFERENCES

1. Bassetti, C. L. A., Kallweit, U., Vignatelli, L., Plazzi, G., Lecendreux, M., Baldin, E., Dolenc‐Groselj, L., Jennum, P., Khatami, R., Manconi, M., Mayer, G., Partinen, M., Pollmächer, T., Reading, P., Santamaria, J., Sonka, K., Dauvilliers, Y., & Lammers, G. J. (2021). European guideline and expert statements on the management of narcolepsy in adults and children. European Journal of Neurology, 28, 2815–2830.
1. Dauvilliers, Y., Lecendreux, M., Lammers, G. J., Franco, P., Poluektov, M., Caussé, C., Lecomte, I., Lecomte, J.‐M., Lehert, P., Schwartz, J.‐C., & Plazzi, G. (2023). Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: A double‐blind, randomised, placebo‐controlled trial. Lancet Neurology, 22, 303–311.
1. Lecendreux, M., Bruni, O., Franco, P., Gringras, P., Konofal, E., Nevsimalova, S., Paiva, T., Partinen, M., Peeters, E., Peraita‐Adrados, R., Plazzi, G., & Poli, F. (2012). Clinical experience suggests that modafinil is an effective and safe treatment for paediatric narcolepsy. Journal of Sleep Research, 21(4), 481–483.
1. Plazzi, G., Clawges, H. M., & Owens, J. A. (2018). Clinical characteristics and burden of illness in pediatric patients with narcolepsy. Pediatric Neurology, 85, 21–32.
1. Postiglione, E., Antelmi, E., Pizza, F., Lecendreux, M., Dauvilliers, Y., & Plazzi, G. (2018). The clinical spectrum of childhood narcolepsy. Sleep Medicine Reviews, 38, 70–85.

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Pharmacological management of narcolepsy in children and adolescents

Affiliations

Pharmacological management of narcolepsy in children and adolescents

Authors

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REFERENCES

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