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Review
. 2023 Dec 1:16:17562848231215585.
doi: 10.1177/17562848231215585. eCollection 2023.

Chemoprevention in hereditary digestive neoplasia: A comprehensive review

Eugénie Chevalier  1 , Robert Benamouzig  2
Affiliations
Review

Chemoprevention in hereditary digestive neoplasia: A comprehensive review

Eugénie Chevalier et al. Therap Adv Gastroenterol. .

Abstract

Hereditary syndromes, such as familial adenomatous polyposis (FAP), MUTYH polyposis or Lynch syndrome, are particularly predisposing to the development of colorectal cancer. These situations have necessitated the development of adapted prevention strategies based largely on reinforced endoscopic surveillance and the search for complementary prevention strategies. This is the case for chemoprevention, which is the long-term administration of chemical agents limiting carcinogenesis, used as primary or secondary prophylaxis. The aim of this review is to present the available literature and the latest advances in chemoprevention in patients with FAP or MUTYH and other polyposis as well as in patients with Lynch syndrome. The main conclusions of the few available guidelines in these situations are also discussed.

Keywords: Lynch syndrome; adenomatous polyposis; chemoprevention; colorectal cancer.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

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