Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb;395(2):133-145.
doi: 10.1007/s00441-023-03849-4. Epub 2023 Dec 5.

Functionalised biomaterials as synthetic extracellular matrices to promote vascularisation and healing of diabetic wounds

Shane Browne  1   2   3 , Noémie Petit  4 , Fabio Quondamatteo  5
Affiliations
Review

Functionalised biomaterials as synthetic extracellular matrices to promote vascularisation and healing of diabetic wounds

Shane Browne et al. Cell Tissue Res. 2024 Feb.

Abstract

Diabetic foot ulcers (DFU) are a type of chronic wound that constitute one of the most serious and debilitating complications associated with diabetes. The lack of clinically efficacious treatments to treat these recalcitrant wounds can lead to amputations for those worst affected. Biomaterial-based approaches offer great hope in this regard, as they provide a template for cell infiltration and tissue repair. However, there is an additional need to treat the underlying pathophysiology of DFUs, in particular insufficient vascularization of the wound which significantly hampers healing. Thus, the addition of pro-angiogenic moieties to biomaterials is a promising strategy to promote the healing of DFUs and other chronic wounds. In this review, we discuss the potential of biomaterials as treatments for DFU and the approaches that can be taken to functionalise these biomaterials such that they promote vascularisation and wound healing in pre-clinical models.

Keywords: Biomaterials; Diabetic foot ulcers; Vascularisation.

PubMed Disclaimer

References

    1. Ali S, Saik JE, Gould DJ et al (2013) Immobilization of cell-adhesive laminin peptides in degradable PEGDA hydrogels influences endothelial cell tubulogenesis. BioResearch Open Access 2:241–249. https://doi.org/10.1089/biores.2013.0021 - DOI - PubMed - PMC
    1. Bainbridge P (2013) Wound healing and the role of fibroblasts. J Wound Care 22:407–412. https://doi.org/10.12968/jowc.2013.22.8.407
    1. Baltzis D, Eleftheriadou I, Veves A (2014) Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights. Adv Ther 31:817–836. https://doi.org/10.1007/s12325-014-0140-x - DOI - PubMed
    1. Barakat M, DiPietro LA, Chen L (2021) Limited treatment options for diabetic wounds: barriers to clinical translation despite therapeutic success in murine models. Adv Wound Care 10:436–460. https://doi.org/10.1089/wound.2020.1254 - DOI
    1. Barr SM (2014) Dehydrated amniotic membrane allograft for treatment of chronic leg ulcers in patients with multiple comorbidities: a case series. Journal of the American College of Clinical Wound Specialists 6:38–45. https://doi.org/10.1016/j.jccw.2016.01.002 - DOI - PubMed

Substances

LinkOut - more resources