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. 2023 Dec 6;23(1):269.
doi: 10.1186/s12902-023-01462-8.

Association between serum osteocalcin and atherosclerosis in Type-2 diabetes mellitus: a cross-sectional study

Vishal Chandra Sharma  1 , Sudha Vidyasagar  1 , Cynthia Amrutha Sukumar  2 , Nanda Krishna B  1 , Sharanya Shree  3
Affiliations

Association between serum osteocalcin and atherosclerosis in Type-2 diabetes mellitus: a cross-sectional study

Vishal Chandra Sharma et al. BMC Endocr Disord. .

Erratum in

Abstract

Background: The past few decades have seen a marked increase in the macrovascular complications of Type-2 diabetes mellitus (T2DM) such as coronary heart disease, peripheral arterial disease, and cerebrovascular disease. This has been predominantly attributed to the increased atherosclerosis in these patients. Atherosclerosis usually remains an asymptomatic condition and this poses a significant challenge in its early diagnosis and timely intervention. Hence, there is an immediate need for exploring novel tools to aid in the early detection of atherosclerosis, especially in T2DM patients. Osteocalcin (OC), synthesized by osteoblasts, is a protein hormone found in the skeletal system. This protein is considered as a marker for bone density and in recent times has been gaining interest due to its protective role in cerebrovascular diseases(CVD).

Methods: We conducted a cross-sectional study and evaluated the association between serum OC levels and atherosclerosis in 113 T2DM patients. Carotid intima-media thickness (CC-IMT) was used as an estimate of atherosclerosis and patients were divided into two groups (CC-IMT < 0.9 and ≥ 0.9). Correlation of serum OC levels and glycemic parameters and lipid profiles were studied and compared between both groups.

Results: There is a significant negative correlation between the CC-IMT estimates and serum OC levels. CC-IMT also has a significant association with other biochemical parameters such as fasting blood sugar, glycated hemoglobin and high-density lipoprotein.

Conclusion: Although the independent association of serum OC could not be established in the T2DM patient population, overall, the results favor low serum OC as a prognostic marker for atherosclerosis.

Keywords: CC-IMT; Carotid intima thickness; Osteocalcin; Type 2 diabetes mellitus; atherosclerosis; inflammation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Correlation of CC-IMT with serum osteocalcin levels. Scatter plot showing negative correlation between CC-IMT and serum osteocalcin. Linear regression line is represented with R2 value value
Fig. 2
Fig. 2
Comparison of serum osteocalcin levels. Box plot with bars showing mean serum OC levels between subjects with CC-IMT ≥ 0.9 mm and those with CC-IMT < 0.9 mm. the error bars represent standard error mean. **, represents statistical significance with a p-value < 0.01
Fig. 3
Fig. 3
Association of serum OC levels with macrovascular complications. A. Mean serum OC levels in different groups with macrovascular (MV) or subclinical (SC) complications. B Serum OC and MV complications in groups with CC-IMT < 0.9 and CC-IMT ≥ 0.9. Error bars represent standard error mean. **, represents statistical significance with a p-value < 0.01
See this image and copyright information in PMC

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