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Review
. 2024 Mar 1;31(2):126-135.
doi: 10.1097/PAP.0000000000000423. Epub 2023 Dec 6.

Contemporary Updates on Sex Cord-stromal Tumors of the Testis

Andrés M Acosta  1 , Muhammad T Idrees  1 , Daniel M Berney  2 , Maurizio Colecchia  3
Affiliations
Review

Contemporary Updates on Sex Cord-stromal Tumors of the Testis

Andrés M Acosta et al. Adv Anat Pathol. .

Abstract

Testicular sex cord-stromal tumors (TSCSTs) are relatively rare, representing ~5% of testicular neoplasms overall. Historically, TSCSTs have been classified into 3 major entities: Leydig cell tumor, Sertoli cell tumor, and granulosa cell tumor. In recent years, immunophenotypic and molecular analyses have led to a more detailed understanding of the biological and genomic features of these neoplasms, resulting in the description of new entities, some of which have been included in the latest WHO classification. This review summarizes novel histopathologic, clinical, and molecular findings that may lead to a reappraisal of established concepts and help improve the diagnosis and clinical management of TSCSTs in the coming years.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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