. 2023 Dec 1;9(4):e003578.

doi: 10.1136/rmdopen-2023-003578.

Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry

Antonio Vitale^#^{1

2}, Valeria Caggiano^#^{3

2}, Giuseppe Lopalco⁴, Henrique A Mayrink Giardini⁵, Francesco Ciccia⁶, Ibrahim A Almaghlouth^{7

8}, Piero Ruscitti⁹, Petros P Sfikakis¹⁰, Abdurrahman Tufan¹¹, Lorenzo Dagna^{12

13}, Roberto Giacomelli^{14

15}, Andrea Hinojosa-Azaola¹⁶, Gafaar Ragab^{17

18}, Haner Direskeneli¹⁹, Lampros Fotis²⁰, Jurgen Sota^{3

2}, Florenzo Iannone⁴, Maria Morrone⁴, Isabele Parente de Brito Antonelli⁵, Marilia Ambiel Dagostin⁵, Daniela Iacono⁶, Martina Patrone⁶, Kazi Asfina⁸, Fehaid Alanazi⁷, Ilenia Di Cola⁹, Carla Gaggiano^{3

2}, Maria G Tektonidou¹⁰, Riza Can Kardas¹¹, Hamit Kucuk¹¹, Corrado Campochiaro^{12

13}, Alessandro Tomelleri^{12

13}, Luca Navarini^{14

15}, Onorina Berardicurti^{14

15}, Eduardo Martín-Nares¹⁶, Jiram Torres-Ruiz¹⁶, Ayman Abdel-Monem Ahmed Mahmoud¹⁷, Fatma Alibaz-Oner¹⁹, Katerina Kourtesi²⁰, Maria Tarsia^{2

21}, Paolo Sfriso²², Joanna Makowska²³, Marcello Govoni²⁴, Francesco La Torre²⁵, Maria Cristina Maggio²⁶, Sara Monti^{27

28}, Emanuela Del Giudice²⁹, Giacomo Emmi^{30

31}, Elena Bartoloni³², José Hernández-Rodríguez³³, Verónica Gómez-Caverzaschi³³, Armin Maier³⁴, Gabriele Simonini³⁵, Annamaria Iagnocco³⁶, Giovanni Conti³⁷, Alma Nunzia Olivieri³⁸, Amato De Paulis^{39

40}, Alberto Lo Gullo⁴¹, Ombretta Viapiana⁴², Ewa Wiesik-Szewczyk⁴³, Sukran Erten⁴⁴, Benson Ogunjimi^{45

46

47

48}, Francesco Carubbi⁴⁹, Samar Tharwat^{50

51}, Katerina Laskari⁵², Stefania Costi⁵³, Paola Triggianese^{54

55}, Anastasios Karamanakos⁵⁶, Alessandro Conforti⁵⁷, Micol Frassi⁵⁸, Gian Domenico Sebastiani⁵⁹, Antonio Gidaro⁶⁰, Angela Mauro⁶¹, Alberto Balistreri⁶², Claudia Fabiani^{2

63}, Bruno Frediani^{3

2}, Luca Cantarini^{1

2}

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy cantariniluca@hotmail.com vitale.reumatologia@gmail.com.
² Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
³ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
⁴ Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
⁵ Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
⁶ Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.
⁷ Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁸ College of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁹ Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.
¹⁰ Joint Academic Rheumatology Program, Medical School, National and Kapodistrian, University of Athens, Athens, Greece.
¹¹ Department of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, Turkey.
¹² Division of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.
¹³ Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
¹⁴ Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
¹⁵ Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome "Campus Biomedico" School of Medicine, Rome, Italy.
¹⁶ Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.
¹⁷ Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Cairo University, Giza, Egypt.
¹⁸ Faculty of Medicine, Newgiza University, 6th of October City, Egypt.
¹⁹ Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey.
²⁰ Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
²¹ Clinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.
²² Rheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
²³ Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
²⁴ Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy.
²⁵ Department of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari Aldo Moro, Bari, Italy.
²⁶ University Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy.
²⁷ Department of Internal Medicine and Therapeutics, University of Pavia; early Arthritis Clinic, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
²⁸ Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
²⁹ Pediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, University of Rome La Sapienza, Rome, Italy.
³⁰ Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
³¹ Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC, Australia.
³² Rheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
³³ Department of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain.
³⁴ Rheumatology Unit, Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy.
³⁵ NEUROFARBA Department, Rheumatology Unit, Meyer Children's Hospital IRCCS, University of Florence, Firenze, Italy.
³⁶ Academic Rheumatology Centre, Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italy.
³⁷ Pediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), "G. Martino", Messina, Italy.
³⁸ Department of Woman, Child and of General and Specialized Surgery, University of Campania Luigi Vanvitelli, Napoli, Italy.
³⁹ Department of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Napoli, Italy.
⁴⁰ Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II, Naples, Italy.
⁴¹ Unit of Rheumatology, Department of Medicine, ARNAS Garibaldi Hospital, Catania, Italy.
⁴² Rheumatology Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
⁴³ Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Poland Ministry of Interior and Administration, Warszawa, Poland.
⁴⁴ Department of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yildirim Beyazit Universitesi, Ankara, Turkey.
⁴⁵ Department of Paediatrics, University Hospital Antwerp, Edegem, Belgium.
⁴⁶ Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp, Antwerp, Belgium.
⁴⁷ Antwerp Center for Translational Immunology and Virology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
⁴⁸ Center for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
⁴⁹ Department of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L'Aquila and ASL Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, L'Aquila, Italy.
⁵⁰ Rheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt.
⁵¹ Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt.
⁵² Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece.
⁵³ Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milano, Italy.
⁵⁴ Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁵⁵ PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy.
⁵⁶ Joint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
⁵⁷ U.O.Medicina Generale, Ospedale San Paolo di Civitavecchia, ASL Roma 4, Civitavecchia, Rome, Italy.
⁵⁸ Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Brescia, Brescia, Italy.
⁵⁹ UOC di Reumatologia, Azienda Ospedaliera San Camillo Forlanini, Roma, Italy.
⁶⁰ Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Milan, Italy.
⁶¹ Pediatric Unit, Fatebenefratelli Hospital, Milan, Milan.
⁶² Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
⁶³ Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

^# Contributed equally.

PMID: 38053457
PMCID: PMC10693888
DOI: 10.1136/rmdopen-2023-003578

Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry

Antonio Vitale et al. RMD Open. 2023.

. 2023 Dec 1;9(4):e003578.

doi: 10.1136/rmdopen-2023-003578.

Authors

Affiliations

¹ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy cantariniluca@hotmail.com vitale.reumatologia@gmail.com.
² Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
³ Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
⁴ Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
⁵ Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
⁶ Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy.
⁷ Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁸ College of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁹ Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.
¹⁰ Joint Academic Rheumatology Program, Medical School, National and Kapodistrian, University of Athens, Athens, Greece.
¹¹ Department of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, Turkey.
¹² Division of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.
¹³ Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
¹⁴ Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
¹⁵ Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome "Campus Biomedico" School of Medicine, Rome, Italy.
¹⁶ Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico.
¹⁷ Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Cairo University, Giza, Egypt.
¹⁸ Faculty of Medicine, Newgiza University, 6th of October City, Egypt.
¹⁹ Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey.
²⁰ Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
²¹ Clinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, Italy.
²² Rheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
²³ Department of Rheumatology, Medical University of Lodz, Lodz, Poland.
²⁴ Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy.
²⁵ Department of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari Aldo Moro, Bari, Italy.
²⁶ University Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy.
²⁷ Department of Internal Medicine and Therapeutics, University of Pavia; early Arthritis Clinic, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
²⁸ Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
²⁹ Pediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, University of Rome La Sapienza, Rome, Italy.
³⁰ Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
³¹ Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC, Australia.
³² Rheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
³³ Department of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain.
³⁴ Rheumatology Unit, Department of Medicine, Central Hospital of Bolzano, Bolzano, Italy.
³⁵ NEUROFARBA Department, Rheumatology Unit, Meyer Children's Hospital IRCCS, University of Florence, Firenze, Italy.
³⁶ Academic Rheumatology Centre, Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italy.
³⁷ Pediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), "G. Martino", Messina, Italy.
³⁸ Department of Woman, Child and of General and Specialized Surgery, University of Campania Luigi Vanvitelli, Napoli, Italy.
³⁹ Department of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Napoli, Italy.
⁴⁰ Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II, Naples, Italy.
⁴¹ Unit of Rheumatology, Department of Medicine, ARNAS Garibaldi Hospital, Catania, Italy.
⁴² Rheumatology Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
⁴³ Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Poland Ministry of Interior and Administration, Warszawa, Poland.
⁴⁴ Department of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yildirim Beyazit Universitesi, Ankara, Turkey.
⁴⁵ Department of Paediatrics, University Hospital Antwerp, Edegem, Belgium.
⁴⁶ Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp, Antwerp, Belgium.
⁴⁷ Antwerp Center for Translational Immunology and Virology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
⁴⁸ Center for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
⁴⁹ Department of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L'Aquila and ASL Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, L'Aquila, Italy.
⁵⁰ Rheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt.
⁵¹ Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt.
⁵² Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece.
⁵³ Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milano, Italy.
⁵⁴ Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
⁵⁵ PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy.
⁵⁶ Joint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
⁵⁷ U.O.Medicina Generale, Ospedale San Paolo di Civitavecchia, ASL Roma 4, Civitavecchia, Rome, Italy.
⁵⁸ Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Brescia, Brescia, Italy.
⁵⁹ UOC di Reumatologia, Azienda Ospedaliera San Camillo Forlanini, Roma, Italy.
⁶⁰ Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Milan, Italy.
⁶¹ Pediatric Unit, Fatebenefratelli Hospital, Milan, Milan.
⁶² Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
⁶³ Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

^# Contributed equally.

PMID: 38053457
PMCID: PMC10693888
DOI: 10.1136/rmdopen-2023-003578

Abstract

Objective: Still's disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still's disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still's disease.

Methods: Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still's disease.

Results: A total of 411 patients suffering from Still's disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still's disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments.

Conclusions: Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still's disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still's disease is the same clinical condition arising in different ages.

Keywords: Child; Epidemiology; Still's Disease, Adult-Onset.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Flow diagram showcasing the distribution of the enrolled AIDA patients into the three study groups (pediatric-onset, adult-onset and elderly-onset patients) and the fulfilment of classification criteria used before and after the age of 16 (ILAR criteria, PRINTO criteria, Yamaguchi criteria, Fautrel criteria14). AIDA, AutoInflammatory Disease Alliance, ILAR, International League of Associations for Rheumatology; PRINTO, Pediatric Rheumatology International Trials Organization.

**Figure 2**
Frequency of use of the different conventional disease-modifying antirheumatic drugs (cDMARDs) in the different groups (pediatric-onset, adult-onset and elderly-onset patients).

**Figure 3**
Kaplan-Meier curves with p values obtained with the Log-rank test. The drug survival was assessed in the three age groups (pediatric, adult and elderly onset) for anakinra (A), canakinumab (B), tocilizumab (C), and tumour necrosis factor (TNF) inhibitors.

See this image and copyright information in PMC

References

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Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry

Affiliations

Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

MeSH terms

LinkOut - more resources

Full Text Sources

Medical