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Comment
. 2023 Dec 5;35(12):2095-2096.
doi: 10.1016/j.cmet.2023.11.007.

All hands on deck: Adipocytes lept-in to drive nerve regeneration

Alina Rashid  1 , Qin Wang  1 , Yuanquan Song  2
Affiliations
Comment

All hands on deck: Adipocytes lept-in to drive nerve regeneration

Alina Rashid et al. Cell Metab. .

Abstract

The glial metabolic state instructs nerve regeneration. In this issue of Cell Metabolism, Sundaram, Schütza, Schröter, et al. demonstrate that nerve injury induces adipocytes-glia signaling via leptin, thereby modulating glial metabolism and driving nerve regeneration.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Adipocyte leptin drives Schwann cell metabolic adaptation to nerve injury
Adipocytes increase leptin release in response to peripheral nerve injury, and repair Schwann cells elevate leptin receptor expression accordingly. Leptin signaling in repair Schwann cells upregulate autophagy, reflected by LC3B lipidation and p62 accumulation, and mitochondrial respiration, which act together to potentially ensure the efficient breakdown of myelin debris to facilitate future nerve repair and remyelination. Further investigations are warranted to substantiate this hypothesis. Monocarboxylates, such as lactate, are also released from Schwann cells to axons following nerve injury to promote neural repair. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.
    Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM, Fledrich R. Sundaram VK, et al. Cell Metab. 2023 Dec 5;35(12):2136-2152.e9. doi: 10.1016/j.cmet.2023.10.017. Epub 2023 Nov 20. Cell Metab. 2023. PMID: 37989315 Free PMC article.

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