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Comment
. 2023 Dec 5;35(12):2097-2099.
doi: 10.1016/j.cmet.2023.11.006.

mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination

Estela Jacinto  1
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mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination

Estela Jacinto. Cell Metab. .
Free article

Abstract

Nutrient availability is conveyed to the mechanistic target of rapamycin (mTOR), which couples metabolic processes with cell growth and proliferation. How mTOR itself is modulated by amino acid levels remains poorly understood. Ge and colleagues now demonstrate that broad sensing of uncharged tRNAs by GCN2/FBXO22 inactivates mTOR complex 1 (mTORC1) via mTOR ubiquitination.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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