Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Jan;23(1):21.
doi: 10.1038/d41573-023-00203-9.

Antibodies achieve leptin balancing act

M Teresa Villanueva
Comment

Antibodies achieve leptin balancing act

M Teresa Villanueva. Nat Rev Drug Discov. 2024 Jan.
No abstract available

Keywords: Drug discovery; Metabolism; Obesity; Psychiatric disorders; Therapeutics.

PubMed Disclaimer

Comment on

  • Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders.
    Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE. Zhao S, et al. Sci Transl Med. 2023 Nov 22;15(723):eade8460. doi: 10.1126/scitranslmed.ade8460. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992151 Free PMC article.
  • Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
    Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA. Altarejos JY, et al. Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992152 Clinical Trial.

References

    1. Altarejos, J. Y. et al. Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency. Sci. Transl Med. 15, eadd4897 (2023). - PubMed - DOI
    1. Zhao, S. et al. Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders. Sci. Transl Med. 15, eade8460 (2023). - PubMed - DOI

LinkOut - more resources