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. 2023 Dec 7;23(1):272.
doi: 10.1186/s12902-023-01523-y.

Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes

Zhen Liu #  1 , Yue Peng #  2 , Supeng Li  1 , Yusheng Lin  2 , Yunfeng Huang  2 , Wenting Chen  3 , Chunhua Bao  3 , Zengxian Zhou  1 , Zhuofeng Lin  4   5   6 , Liangmiao Chen  7
Affiliations

Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes

Zhen Liu et al. BMC Endocr Disord. .

Abstract

Objectives: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia and metabolic stress, involved in the stepwise development of cardiovascular complications. Fibroblast growth factor 21 (FGF21) is a novel hepatokine involved in regulating glucose and lipid metabolism, and has been linked to the prediction, treatment, and improvement of prognosis in multiple cardiovascular diseases (CVDs). The aim of this study is to explore the relationship between FGF21 levels and vascular diseases (VDs) including carotid atherosclerosis (CAS) and hypertension (HP) in patients with T2DM.

Methods: Baseline serum FGF21 was determined in a cross-sectional study of 701 patients with T2DM and 258 healthy control.

Results: The morbidity of CAS was increased in T2DM patients with HP as compared with those without (p < 0.001). The average serum FGF21 level of healthy was [123.9 (67.2-219.3)]. Baseline FGF21 was significantly higher in those who developed CAS or HP than in those who did not [305.9 (177.2-508.4) vs. 197.2 (129.7-308.3) pg/mL, p < 0.001]. In addition, an elevated serum FGF21 was observed in T2DM patients with HP and CAS than that of T2DM patients with CAS or HP [550.5 (312.6-711.3) vs. 305.9 pg/mL, p < 0.001]. Serum FGF21 levels were positively correlated with body mass index and carotid intima media thicknes (p < 0.05), the association remained significant after adjusting for age and T2DM duration. Furthermore, the multinomial logistic regression showed that serum FGF21 was independently associated with CAS and HP in patients with T2DM after adjustment for demographic and traditional VDs risk factors (p < 0.001).

Conclusions: Baseline FGF21 is elevated in VDs during diabetes, changes of serum FGF21 levels were appropriately matched to metabolic stress. FGF21can be used as an independent predictor for diagnosing VDs and predicting prognosis.

Keywords: Carotid Atherosclerosis; Fibroblast growth factor 21; Hypertension; Type 2 Diabetes Mellitus; Vascular Diseases.

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Conflict of interest statement

There were no conflicts of interest.

Figures

Fig. 1
Fig. 1
Serum FGF21 levels in T2DM patients with or without relevant VDs including CAS and/or HP
See this image and copyright information in PMC

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