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Review
. 2023 Nov 10;9(11):e22017.
doi: 10.1016/j.heliyon.2023.e22017. eCollection 2023 Nov.

The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease

Cuiting Wei  1   2 , Chao Wang  1   2 , Run Li  1   2 , Yunfeng Bai  2 , Xue Wang  2 , Qingyun Fang  2 , Xiangmei Chen  1   2 , Ping Li  2
Affiliations
Review

The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease

Cuiting Wei et al. Heliyon. .

Abstract

Abelmoschus manihot (A.manihot) is a herbaceous flowering medicinal plant and flavonoids are its main pharmacological active ingredients. A.manihot is listed in the 2020 edition of the Chinese Pharmacopoeia for the treatment of chronic kidney disease (CKD). A.manihot significantly reduces proteinuria in CKD, and the effectiveness and safety of A.manihot in the treatment including primary glomerulonephropathy and diabetic kidney disease (DKD) have been proved by several randomized controlled trials (RCT). Emerging pharmacological studies have explored the potential active small molecules and the underlying mechanisms in A.manihot. The active constituents of A.manihot are mainly seven flavonoids, including hibifolin, hyperoside, isoquercetin, rutin, quercetin, myricetin, and quercetin-3-O-robinobioside. The mechanisms of action mainly include alleviating renal fibrosis, reducing the inflammatory response and decreasing the apoptosis of podocytes. In this review, we summarize the updated information of active components and molecular mechanisms of A.manihot on chronic kidney disease.

Keywords: Abelmoschus manihot; Active components; Chronic kidney disease; Diabetic kidney disease; Molecular mechanism.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Li N., et al. Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases. Phytother Res. 2021;35(1):198–206. - PMC - PubMed
    1. Zhang L., et al. Efficacy and safety of Abelmoschus manihot for primary glomerular disease: a prospective, multicenter randomized controlled clinical trial. Am. J. Kidney Dis. 2014;64(1):57–65. - PubMed
    1. Du L.Y., et al. Comparative characterization of nucleotides, nucleosides and nucleobases in Abelmoschus manihot roots, stems, leaves and flowers during different growth periods by UPLC-TQ-MS/MS. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2015;1006:130–137. - PubMed
    1. Li P., et al. Efficacy and safety of Abelmoschus manihot for IgA nephropathy: a multicenter randomized clinical trial. Phytomedicine. 2020;76 - PubMed
    1. Sun X., et al. Efficacy and safety of Abelmoschus manihot in treating chronic kidney diseases: a multicentre, open-label and single-arm clinical trial. Phytomedicine. 2022;99 - PubMed

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