Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

Md Yuzaiful Md Yusof^{1

2}, Eve M D Smith^{3

4}, Sammy Ainsworth⁵, Kate Armon⁶, Michael W Beresford^{3

4}, Morgan Brown⁵, Lindsey Cherry⁷, Christopher J Edwards⁸, Kalveer Flora⁹, Rebecca Gilman¹⁰, Bridget Griffiths¹¹, Caroline Gordon¹⁰, Paul Howard⁵, David Isenberg¹², Natasha Jordan¹³, Arvind Kaul¹⁴, Peter Lanyon^{15

16}, Philip M Laws¹⁷, Liz Lightsone¹⁸, Hanna Lythgoe¹⁹, Christian D Mallen²⁰, Stephen D Marks^{21

22}, Naomi Maxwell⁵, Elena Moraitis^{23

24}, Clare Nash²⁵, Ruth J Pepper²⁶, Clarissa Pilkington²³, Antonios Psarras²⁷, Heather Rostron^{1

28}, Jade Skeates²⁹, Sarah Skeoch²⁹, Dalila Tremarias⁵, Chris Wincup³⁰, Asad Zoma³¹, Edward M Vital^{1

2}

Affiliations

¹ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK.
² NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
³ Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool Faculty of Health and Life Sciences, Liverpool, UK.
⁴ Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
⁵ LUPUS UK, Romford, UK.
⁶ Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
⁷ School of Health Sciences, University of Southampton, Southampton, UK.
⁸ Musculoskeletal Research Unit, NIHR Southampton Clinical Research Facility, University Hospital Southampton, Southampton, UK.
⁹ Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Harrow, UK.
¹⁰ Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
¹¹ Department of Rheumatology, Freeman Hospital, Newcastle, UK.
¹² Centre for Rheumatology, Division of Medicine, University College London, London, UK.
¹³ Department of Adolescent Rheumatology, St James's Hospital and Children's Health Ireland, Dublin, Ireland.
¹⁴ Department of Rheumatology, St George's University Hospitals NHS Foundation Trust, London, UK.
¹⁵ Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
¹⁶ Nottingham University Hospitals NHS Trust, Nottingham, UK.
¹⁷ Department of Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
¹⁸ Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK.
¹⁹ Department of Paediatric Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK.
²⁰ Centre for Musculoskeletal Health Research, School of Medicine, Keele University, Keele, UK.
²¹ Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
²² NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
²³ Department of Paediatric Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
²⁴ Infection, Immunity and Inflammation Department, University College of London Great Ormond Street Institute of Child Health, London, UK.
²⁵ Pharmacy Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
²⁶ Department of Renal Medicine, Royal Free Hospital, London, UK.
²⁷ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
²⁸ Leeds Children's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
²⁹ Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
³⁰ Department of Clinical and Academic Rheumatology, King's College Hospital NHS Foundation Trust, London, UK.
³¹ Lanarkshire Centre for Rheumatology, Hairmyres Hospital, East Kilbride, Scotland, UK.

PMID: 38058676
PMCID: PMC10695902
DOI: 10.1093/rap/rkad093

Review

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

Md Yuzaiful Md Yusof et al. Rheumatol Adv Pract. 2023.

. 2023 Dec 5;7(3):rkad093.

doi: 10.1093/rap/rkad093. eCollection 2023.

Authors

Affiliations

¹ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK.
² NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
³ Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool Faculty of Health and Life Sciences, Liverpool, UK.
⁴ Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
⁵ LUPUS UK, Romford, UK.
⁶ Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
⁷ School of Health Sciences, University of Southampton, Southampton, UK.
⁸ Musculoskeletal Research Unit, NIHR Southampton Clinical Research Facility, University Hospital Southampton, Southampton, UK.
⁹ Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Harrow, UK.
¹⁰ Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
¹¹ Department of Rheumatology, Freeman Hospital, Newcastle, UK.
¹² Centre for Rheumatology, Division of Medicine, University College London, London, UK.
¹³ Department of Adolescent Rheumatology, St James's Hospital and Children's Health Ireland, Dublin, Ireland.
¹⁴ Department of Rheumatology, St George's University Hospitals NHS Foundation Trust, London, UK.
¹⁵ Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
¹⁶ Nottingham University Hospitals NHS Trust, Nottingham, UK.
¹⁷ Department of Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
¹⁸ Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, UK.
¹⁹ Department of Paediatric Rheumatology, Manchester University NHS Foundation Trust, Manchester, UK.
²⁰ Centre for Musculoskeletal Health Research, School of Medicine, Keele University, Keele, UK.
²¹ Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
²² NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
²³ Department of Paediatric Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
²⁴ Infection, Immunity and Inflammation Department, University College of London Great Ormond Street Institute of Child Health, London, UK.
²⁵ Pharmacy Department, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
²⁶ Department of Renal Medicine, Royal Free Hospital, London, UK.
²⁷ Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
²⁸ Leeds Children's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
²⁹ Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
³⁰ Department of Clinical and Academic Rheumatology, King's College Hospital NHS Foundation Trust, London, UK.
³¹ Lanarkshire Centre for Rheumatology, Hairmyres Hospital, East Kilbride, Scotland, UK.

PMID: 38058676
PMCID: PMC10695902
DOI: 10.1093/rap/rkad093

Abstract

The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood. The guideline will be developed with people with SLE as an important target audience in addition to healthcare professionals. It will include guidance related to emerging approved therapies and account for National Institute for Health and Care Excellence Technology Appraisals, National Health Service England clinical commissioning policies and national guidance relevant to SLE. The guideline will be developed using the methods and rigorous processes outlined in 'Creating Clinical Guidelines: Our Protocol' by the British Society for Rheumatology.

Keywords: biologic DMARDs; guideline; lupus nephritis; management; systemic lupus erythematosus.

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References

1. Gordon C, Amissah-Arthur MB, Gayed M. et al. The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults. Rheumatology (Oxford) 2018;57:e1–45. - PubMed
1. Fanouriakis A, Kostopoulou M, Cheema K. et al. 2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis. Ann Rheum Dis 2020;79:713–23. - PubMed
1. Rovin BH, Teng YKO, Ginzler EM. et al. Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2021;397:2070–80. - PubMed
1. Furie R, Rovin BH, Houssiau F. et al. Two-year, randomized, controlled trial of belimumab in lupus nephritis. N Engl J Med 2020;383:1117–28. - PubMed
1. Palmer SC, Tunnicliffe DJ, Singh-Grewal D. et al. Induction and maintenance immunosuppression treatment of proliferative lupus nephritis: a network meta-analysis of randomized trials. Am J Kidney Dis 2017;70:324–36. - PubMed

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Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

Affiliations

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

Authors

Affiliations

Abstract

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources