Review

. 2024 Jul;34(7):4821-4827.

doi: 10.1007/s00330-023-10411-x. Epub 2023 Dec 7.

Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the EFLM Science Committee

Aart J van der Molen¹, Johannes G Krabbe², Ilona A Dekkers¹, Remy W F Geenen³, Marie-France Bellin⁴, Michele Bertolotto⁵, Torkel B Brismar⁶, Janne Cadamuro⁷, Jean-Michel Correas⁸, Gertraud Heinz-Peer⁹, Michel R Langlois¹⁰, Andreas H Mahnken¹¹, Tomris Ozben¹², Carlo C Quattrocchi¹³, Alexander Radbruch¹⁴, Peter Reimer¹⁵, Giles Roditi¹⁶, Laura Romanini¹⁷, Carmen Sebastià¹⁸, Ana-Maria Simundic¹⁹, Fulvio Stacul²⁰, Olivier Clement²¹

Affiliations

¹ Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Enschede, The Netherlands.
³ Department of Radiology, Northwest Clinics, Alkmaar, The Netherlands.
⁴ University Paris-Saclay, AP-HP, University Hospital Bicêtre, Service de Radiologie, BioMaps, Le Kremlin-Bicêtre, France.
⁵ Department of Radiology, University Hospital Trieste, Trieste, Italy.
⁶ Department of Clinical Science, Intervention and Technology, Unit of Radiology, Karolinska Institutet and Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden.
⁷ Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
⁸ Université de Paris, AP-HP, Groupe Hospitalier Necker, DMU Imagina, Service de Radiologie, Paris, France.
⁹ Department of Radiology, Landesklinikum St Pölten, St Pölten, Austria.
¹⁰ Department of Laboratory Medicine, AZ St.-Jan Hospital, Brugge, Belgium.
¹¹ Department of Radiology, Marburg University Hospital, Marburg, Germany.
¹² Department of Clinical Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
¹³ Centre for Medical Sciences - CISMed, University of Trento, Trento, Italy.
¹⁴ Clinic for Diagnostic and Interventional Neuroradiology, University Clinic Bonn, and German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
¹⁵ Department of Radiology, Institute for Diagnostic and Interventional Radiology, Klinikum Karlsruhe, Karlsruhe, Germany.
¹⁶ Department of Radiology, Glasgow Royal Infirmary, Glasgow, UK.
¹⁷ Department of Radiology, ASST Cremona, Cremona, Italy.
¹⁸ Department of Radiology, Hospital Clinic de Barcelona, Barcelona, Spain.
¹⁹ Department of Medical Laboratory Diagnostics, Clinical Hospital Sveti Duh, Zagreb University, Zagreb, Croatia.
²⁰ Department of Radiology, Ospedale Maggiore, Trieste, Italy.
²¹ Université de Paris, AP-HP, Hôpital Européen Georges Pompidou, DMU Imagina, Service de Radiologie, 20 Rue LeBlanc, F-75015, Paris, France. olivier.clement@aphp.fr.

PMID: 38060004
PMCID: PMC11213772
DOI: 10.1007/s00330-023-10411-x

Review

Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the EFLM Science Committee

Aart J van der Molen et al. Eur Radiol. 2024 Jul.

. 2024 Jul;34(7):4821-4827.

doi: 10.1007/s00330-023-10411-x. Epub 2023 Dec 7.

Authors

Affiliations

¹ Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Enschede, The Netherlands.
³ Department of Radiology, Northwest Clinics, Alkmaar, The Netherlands.
⁴ University Paris-Saclay, AP-HP, University Hospital Bicêtre, Service de Radiologie, BioMaps, Le Kremlin-Bicêtre, France.
⁵ Department of Radiology, University Hospital Trieste, Trieste, Italy.
⁶ Department of Clinical Science, Intervention and Technology, Unit of Radiology, Karolinska Institutet and Department of Radiology, Karolinska University Hospital in Huddinge, Stockholm, Sweden.
⁷ Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
⁸ Université de Paris, AP-HP, Groupe Hospitalier Necker, DMU Imagina, Service de Radiologie, Paris, France.
⁹ Department of Radiology, Landesklinikum St Pölten, St Pölten, Austria.
¹⁰ Department of Laboratory Medicine, AZ St.-Jan Hospital, Brugge, Belgium.
¹¹ Department of Radiology, Marburg University Hospital, Marburg, Germany.
¹² Department of Clinical Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
¹³ Centre for Medical Sciences - CISMed, University of Trento, Trento, Italy.
¹⁴ Clinic for Diagnostic and Interventional Neuroradiology, University Clinic Bonn, and German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany.
¹⁵ Department of Radiology, Institute for Diagnostic and Interventional Radiology, Klinikum Karlsruhe, Karlsruhe, Germany.
¹⁶ Department of Radiology, Glasgow Royal Infirmary, Glasgow, UK.
¹⁷ Department of Radiology, ASST Cremona, Cremona, Italy.
¹⁸ Department of Radiology, Hospital Clinic de Barcelona, Barcelona, Spain.
¹⁹ Department of Medical Laboratory Diagnostics, Clinical Hospital Sveti Duh, Zagreb University, Zagreb, Croatia.
²⁰ Department of Radiology, Ospedale Maggiore, Trieste, Italy.
²¹ Université de Paris, AP-HP, Hôpital Européen Georges Pompidou, DMU Imagina, Service de Radiologie, 20 Rue LeBlanc, F-75015, Paris, France. olivier.clement@aphp.fr.

PMID: 38060004
PMCID: PMC11213772
DOI: 10.1007/s00330-023-10411-x

Abstract

The Contrast Media Safety Committee of the European Society of Urogenital Radiology has, together with the Preanalytical Phase Working Group of the EFLM Science Committee, reviewed the literature and updated its recommendations to increase awareness and provide insight into these interferences. CLINICAL RELEVANCE STATEMENT: Contrast Media may interfere with clinical laboratory tests. Awareness of potential interference may prevent unwanted misdiagnosis. KEY POINTS: • Contrast Media may interfere with clinical laboratory tests; therefore awareness of potential interference may prevent unwanted misdiagnosis. • Clinical Laboratory tests should be performed prior to radiological imaging with contrast media or alternatively, blood or urine collection should be delayed, depending on kidney function.

Keywords: Analytical chemistry; Clinical laboratory techniques; Clinical practice guideline; Contrast agents; Diagnostic error.

PubMed Disclaimer

Conflict of interest statement

The authors of this manuscript declare relationships with the following companies:

Aart J. van der Molen: Guerbet

Johannes G. Krabbe: none

Ilona A. Dekkers: Guerbet

Remy W.F. Geenen: none

Marie-France Bellin: is a member of the European Radiology Advisory Editorial Board but has not taken part in the review or selection process of this article.

Michele Bertolotto: none

Torkel B Brismar: is a member of the European Radiology Scientific Editorial Board but has not taken part in the review or selection process of this article.

Janne Cadamuro: none

Jean-Michel Correas: Bracco Imaging, Guerbet

Gertraud Heinz-Peer: none

Michel R. Langlois: none

Andreas H. Mahnken: none

Tomris Ozben: none

Carlo C. Quattrocchi: Bracco Imaging, Guerbet, Bayer Healthcare, GE Healthcare

Alexander Radbruch: none

Peter Reimer: none

Giles Roditi: none

Laura Romanini: none

Carmen Sebastià: none

Ana-Maria Simundic: none

Fulvio Stacul: none

Olivier Clement: Bracco Imaging, Guerbet, Bayer Healthcare

The contrast media companies Bayer Healthcare, Bracco Imaging, GE Healthcare, and Guerbet are consultants to the ESUR Contrast Media Safety Committee and participate in all scientific discussions but are not involved in any of the final recommendations.

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Incidence, outcome, and risk factors of contrast media extravasation injury during contrast-enhanced computed tomography scans: an observational cohort study.
Wang L, Chen Q, Liu H, Wang X, Qian Q, Xu M, Ma L, Wang X. Wang L, et al. Quant Imaging Med Surg. 2025 Aug 1;15(8):7338-7351. doi: 10.21037/qims-24-2332. Epub 2025 Jul 25. Quant Imaging Med Surg. 2025. PMID: 40785883 Free PMC article.

References

1. Doorenbos CJ, Ozyilmaz A, van Wijnen M. Severe pseudohypocalcemia after gadolinium-enhanced magnetic resonance angiography. N Engl J Med. 2003;349(8):817–818. doi: 10.1056/NEJM200308213490822. - DOI - PubMed
1. Otnes S, Fogh-Andersen N, Rømsing J, Thomsen HS. Analytical interference by contrast agents in biochemical assays. Contrast Media Mol Imaging. 2017;2017:1323802. doi: 10.1155/2017/1323802. - DOI - PMC - PubMed
1. Morcos SK, Thomsen HS, Exley CM; Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR) (2005) Contrast media: interactions with other drugs and clinical tests. Eur Radiol 15:1463-1468 - PubMed
1. Dimopoulos MA, Moreau P, Terpos E, et al. Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Ann Oncol. 2021;32:309–322. doi: 10.1016/j.annonc.2020.11.014. - DOI - PubMed
1. Quirós C, Cillero AI, Bretaña L, García M, Prieto B, Álvarez FV. In vivo interference of Ioversol in serum and urine capillary electrophoresis: an optimized protocol for sample collection. Clin Chem Lab Med. 2018;56:e53–e55. doi: 10.1515/cclm-2017-0509. - DOI - PubMed

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Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the EFLM Science Committee

Affiliations

Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the EFLM Science Committee

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Abstract

Conflict of interest statement

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