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. 1986;67(3-4):275-85.
doi: 10.1007/BF01243353.

Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level

L Nilsson, A Nordberg, J Hardy, P Wester, B Winblad

Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level

L Nilsson et al. J Neural Transm. 1986.

Abstract

A technique was developed, which made it possible to study the in vitro release of 3H-acetylcholine (3H-ACh) from human post mortem brain tissue, collected with short post-mortem delay (2,5-22 hours), both from controls and patients with Alzheimer's disease (AD/SDAT). The tritium (3H) release was investigated during potassium stimulation, and AD/SDAT cortical slices were found to release a decreased amount of 3H compared to control brain slices. Physostigmine, 10(-5) and 10(-4) M, has no significant effect on the release of 3H from control slices, while physostigmine 10(-4) M increased the evoked release from AD/SDAT brain slices over threefold, nearly to the control level.

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