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. 2024 Jan 1;38(1):131-133.
doi: 10.1097/QAD.0000000000003734. Epub 2023 Dec 7.

Effect of influenza vaccination on the persistence of HIV reservoirs and immunologic parameters in people with HIV

Jana Blazkova  1 , Victoria Shi  1 , Maegan R Manning  1 , Brooke D Kennedy  1 , J Shawn Justement  1 , Lauren Praiss  1 , Kathleen Gittens  2 , Catherine A Seamon  2 , M Ali Rai  1 , Susan Moir  1 , Tae-Wook Chun  1
Affiliations

Effect of influenza vaccination on the persistence of HIV reservoirs and immunologic parameters in people with HIV

Jana Blazkova et al. AIDS. .
No abstract available

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Conflict of interest statement

Conflict of interest

The authors have declared that no conflict of interest exists.

Figures

Fig. 1.
Fig. 1.. Dynamics of virologic and immunologic parameters in 17 PLWH on effective ART prior to and following quadrivalent influenza vaccination.
(a) Levels of CD4+ and CD8+ T cell count. (b) Levels of plasma viremia. (c) Frequency of CD4+ T cells carrying cell-associated HIV RNA, intact, 5’ and 3’ defective HIV DNA. (d) Plasma levels of immune activation/inflammation markers PD-L1, IP-10, IL-2Rα, IL-6, and Granzyme B. Black lines indicate median values. (e) High-dimensional flow cytometric immunophenotyping. Uniform Manifold Approximation and Projection (UMAP) map of T cell clusters identified by FlowSOM clustering and a heatmap showing the level of expression of individual markers in each cluster. Clusters 4, 6, and 7 showed a significant increase two weeks after vaccination compared to the baseline. P values were determined by the Friedman test. Only significant P values are displayed.
See this image and copyright information in PMC

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