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. 2024 Apr;90(4):839-841.
doi: 10.1016/j.jaad.2023.11.051. Epub 2023 Dec 6.

TRBC1 immunohistochemistry distinguishes cutaneous T-cell lymphoma from inflammatory dermatitis: A retrospective analysis of 39 cases

Sarah E Nocco  1 , Mark D Ewalt  2 , Andrea P Moy  2 , Natasha E Lewis  2 , Menglei Zhu  2 , Cecilia Lezcano  2 , Klaus Busam  2 , Melissa Pulitzer  3
Affiliations

TRBC1 immunohistochemistry distinguishes cutaneous T-cell lymphoma from inflammatory dermatitis: A retrospective analysis of 39 cases

Sarah E Nocco et al. J Am Acad Dermatol. 2024 Apr.
No abstract available

Keywords: CTCL; FFPE; TRBC1; cutaneous T-cell lymphoma; flow cytometry lymphoma; formalin-fixed paraffin-embedded; immunohistochemistry; lymphoproliferative disorders.

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Conflict of interest statement

Conflicts of interest The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Figures

Figure 1.
Figure 1.
Skin biopsy specimen from a patient with mycosis fungoides which shows an atypical lymphocytic infiltrate predominantly located in the epidermis. The atypical lymphocytes are diffusely positive for CD3 (A, x400) and negative for TRBC1 (B, x400), consistent with a monotypic-negative TRBC1 expression pattern. The underlying dermal reactive immune infiltrate shows a TRBC1 polytypic expression pattern.
Figure 1.
Figure 1.
Skin biopsy specimen from a patient with mycosis fungoides which shows an atypical lymphocytic infiltrate predominantly located in the epidermis. The atypical lymphocytes are diffusely positive for CD3 (A, x400) and negative for TRBC1 (B, x400), consistent with a monotypic-negative TRBC1 expression pattern. The underlying dermal reactive immune infiltrate shows a TRBC1 polytypic expression pattern.
See this image and copyright information in PMC

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