Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Inés Domínguez-López^{1

2

3}, Polina Galkina¹, Isabella Parilli-Moser^{1

2

3}, Camila Arancibia-Riveros^{1

2

3}, Miguel Ángel Martínez-González^{3

4

5}, Jordi Salas-Salvadó^{3

6

7}, Dolores Corella^{3

8}, Mireia Malcampo⁹, J Alfredo Martínez^{3

10

11}, Lucas Tojal-Sierra^{3

12}, Julia Wärnberg^{3

13}, Jesús Vioque^{14

15}, Dora Romaguera^{3

16}, José López-Miranda^{3

17}, Ramon Estruch^{2

3

18}, Francisco J Tinahones^{3

19}, José Manuel Santos-Lozano^{3

20}, Lluís Serra-Majem^{3

21}, Aurora Bueno-Cavanillas^{16

22}, Josep A Tur^{3

23}, María Rubín-García²⁴, Xavier Pintó^{3

25}, Fernando Fernández-Aranda^{3

26}, Miguel Delgado-Rodríguez^{12

27}, Ana Barabash-Bustelo²⁸, Josep Vidal^{29

30}, Clotilde Vázquez^{3

31}, Lidia Daimiel^{3

32

33}, Emilio Ros^{3

34}, Estefania Toledo^{3

4

5}, Alessandro Atzeni^{3

6

7}, Eva M Asensio^{3

8}, Natàlia Vera⁹, Antonio Garcia-Rios^{3

17}, Laura Torres-Collado^{14

15}, Napoleón Pérez-Farinós^{3

13}, Marian Zulet^{3

10

11}, Alice Chaplin^{3

16}, Rosa Casas^{2

3

18}, Sandra Martín-Peláez²², Jessica Vaquero-Luna^{3

12}, Ana Maria Gómez-Pérez¹⁹, Zenaida Vázquez-Ruiz^{3

4

5}, Sangeetha Shyam^{3

6

7}, Carolina Ortega-Azorín^{3

8}, Natàlia Talens⁹, Patricia J Peña-Orihuela^{3

17}, Alejandro Oncina-Canovas^{14

15}, Javier Diez-Espino^{3

35}, Nancy Babio^{3

6

7}, Montserrat Fitó^{3

9}, Rosa M Lamuela-Raventós^{1

2

3}

Affiliations

¹ Polyphenol Research Group, Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences, Barcelona, Catalunya, Spain.
² Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, Santa Coloma de Gramanet, 08921, Spain.
³ Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
⁴ Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain.
⁵ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁶ Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Grup de Recerca ANut-DSM, Unitat de Nutrició, Reus, Spain.
⁷ Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
⁸ Department of Preventive Medicine, University of Valencia, Valencia, Spain.
⁹ Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d`Investigació Médica (IMIM), Barcelona, Spain.
¹⁰ Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.
¹¹ Precision Nutrition and Cardiovascular Health, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.
¹² Bioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
¹³ EpiPHAAN research group, School of Health Sciences, University of Málaga - Instituto de Investigación Biomédica en Málaga (IBIMA), Málaga, Spain.
¹⁴ CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
¹⁵ Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), Alicante, Spain.
¹⁶ Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
¹⁷ Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
¹⁸ Internal Medicine Service, Hospital Clínic, University of Barcelona, Barcelona, Spain.
¹⁹ Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.
²⁰ Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain.
²¹ Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas de Gran Canaria, Spain.
²² Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.
²³ Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain.
²⁴ Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), Universidad de León, León, Spain.
²⁵ Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
²⁶ Clinical Psychology Unit, University Hospital Bellvitge-IDIBELL and University of Barcelona, Barcelona, Spain.
²⁷ Division of Preventive Medicine, Faculty of Medicine, University of Jaén, Jaén, Spain.
²⁸ Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
²⁹ CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
³⁰ Department of Endocrinology, Institut d` Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.
³¹ Department of Endocrinology and Nutrition, Hospital Fundación Jimenez Díaz, Instituto de Investigaciones Biomédicas IISFJD, University Autonoma, Madrid, Spain.
³² Nutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.
³³ Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
³⁴ Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.
³⁵ Centro de Salud de Tafalla, Gerencia de Atención Primaria, Servicio Navarro de Salud Osasunbidea, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.

PMID: 38062915
DOI: 10.1002/mnfr.202300183

Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Inés Domínguez-López et al. Mol Nutr Food Res. 2024 Jan.

. 2024 Jan;68(2):e2300183.

doi: 10.1002/mnfr.202300183. Epub 2023 Dec 7.

Authors

Affiliations

¹ Polyphenol Research Group, Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences, Barcelona, Catalunya, Spain.
² Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, Santa Coloma de Gramanet, 08921, Spain.
³ Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
⁴ Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, Pamplona, Spain.
⁵ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁶ Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Grup de Recerca ANut-DSM, Unitat de Nutrició, Reus, Spain.
⁷ Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
⁸ Department of Preventive Medicine, University of Valencia, Valencia, Spain.
⁹ Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d`Investigació Médica (IMIM), Barcelona, Spain.
¹⁰ Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.
¹¹ Precision Nutrition and Cardiovascular Health, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.
¹² Bioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
¹³ EpiPHAAN research group, School of Health Sciences, University of Málaga - Instituto de Investigación Biomédica en Málaga (IBIMA), Málaga, Spain.
¹⁴ CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
¹⁵ Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), Alicante, Spain.
¹⁶ Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain.
¹⁷ Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
¹⁸ Internal Medicine Service, Hospital Clínic, University of Barcelona, Barcelona, Spain.
¹⁹ Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.
²⁰ Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain.
²¹ Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas de Gran Canaria, Spain.
²² Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.
²³ Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain.
²⁴ Group of Investigation in Interactions Gene-Environment and Health (GIIGAS), Institute of Biomedicine (IBIOMED), Universidad de León, León, Spain.
²⁵ Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
²⁶ Clinical Psychology Unit, University Hospital Bellvitge-IDIBELL and University of Barcelona, Barcelona, Spain.
²⁷ Division of Preventive Medicine, Faculty of Medicine, University of Jaén, Jaén, Spain.
²⁸ Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
²⁹ CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
³⁰ Department of Endocrinology, Institut d` Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.
³¹ Department of Endocrinology and Nutrition, Hospital Fundación Jimenez Díaz, Instituto de Investigaciones Biomédicas IISFJD, University Autonoma, Madrid, Spain.
³² Nutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain.
³³ Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
³⁴ Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.
³⁵ Centro de Salud de Tafalla, Gerencia de Atención Primaria, Servicio Navarro de Salud Osasunbidea, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.

PMID: 38062915
DOI: 10.1002/mnfr.202300183

Abstract

Scope: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk.

Methods and results: A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM. Mediterranean diet (MedDiet) adherence is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests. Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests. Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.

Conclusions: These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in an older population.

Keywords: Mediterranean diet; PREDIMED-Plus; bioactive compounds; cognition; neurodegeneration.

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References

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Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Affiliations

Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Authors

Affiliations

Abstract

References

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources