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. 1986 Oct;14(5):523-37.
doi: 10.1007/BF01059659.

Implementation and evaluation of control strategies for individualizing dosage regimens, with application to the aminoglycoside antibiotics

D Katz, D Z D'Argenio

Implementation and evaluation of control strategies for individualizing dosage regimens, with application to the aminoglycoside antibiotics

D Katz et al. J Pharmacokinet Biopharm. 1986 Oct.

Abstract

Three strategies are implemented for controlling serum concentrations by determining individualized dosage regimens. The methods incorporate, respectively, nonlinear least squares parameter estimation, Bayesian maximum a posteriori probability estimation, and a stochastic control procedure that minimizes the expected value of an appropriate therapeutic cost. The performance of the three dose regimen calculation strategies was evaluated using Monte Carlo simulations of a typical therapeutic protocol for tobramycin.

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