Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec;274(8):1787-1795.
doi: 10.1007/s00406-023-01721-8. Epub 2023 Dec 8.

A clinical approach to the investigation and management of long COVID associated neuropathic pain

Affiliations
Review

A clinical approach to the investigation and management of long COVID associated neuropathic pain

Rajish Sanjit Kumar Shil et al. Eur Arch Psychiatry Clin Neurosci. 2024 Dec.

Abstract

COVID-19 has been associated with a wide range of ongoing symptoms following recovery from the acute SARS-CoV-2 infection. Around one in three people with COVID-19 develop neurological symptoms with many reporting neuropathic pain and associated symptoms, including paraesthesia, numbness, and dysesthesia. Whilst the pathophysiology of long COVID-19-associated neuropathic pain remains unclear, it is likely to be multifactorial. Early identification, exclusion of common alternative causes, and a biopsychosocial approach to the management of the symptoms can help in relieving the burden of disease and improving the quality of life for patients.

Keywords: COVID-19; Long Covid; Neuropathy; Pain; Paraesthesia.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Accompaniment of Table 2. No specific pattern of pain distribution in long COVID associated neuropathic pain, as can be a combination of the above patterns

References

    1. World Health Organization (WHO) (2021) A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_cond...
    1. Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S (2021) More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep 11:16144. 10.1038/s41598-021-95565-8 - PMC - PubMed
    1. Fernández-de-las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Florencio LL, Cuadrado ML, Plaza-Manzano G, Navarro-Santana M (2021) Prevalence of Post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: a systematic review and meta-analysis. Eur J Int Med 92:55–70. 10.1016/j.ejim.2021.06.009 - PMC - PubMed
    1. Fernández-de-las-Peñas C, Navarro-Santana M, Plaza-Manzano G, Palacios-Ceña A-N (2022) Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived to SARS-CoV-2 infection: a systematic review and meta-analysis. Pain 163:1220–1231. 10.1097/j.pain.0000000000002496 - PubMed
    1. Fernández-de-las-Peñas C, de-la-Llave-Rincón AI, Ortega-Santiago R, Ambite-Quesada S, Gómez-Mayordomo V, Cuadrado ML, Arias-Navalón JA, Hernández-Barrera V, Martín-Guerrero JD, Pellicer-Valero OJ, et al (2021) Prevalence and risk factors of musculoskeletal pain symptoms as long-term post-COVID sequelae in hospitalized COVID-19 survivors: a multicenter study. Pain 10.1097/j.pain.0000000000002564 - PubMed

LinkOut - more resources