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Review
. 2024 Jan;30(1):64-77.
doi: 10.1016/j.cardfail.2023.08.026. Epub 2023 Dec 7.

Research Gaps in Pediatric Heart Failure: Defining the Gaps and Then Closing Them Over the Next Decade

Shahnawaz Amdani  1 , Scott R Auerbach  2 , Neha Bansal  3 , Sharon Chen  4 , Jennifer Conway  5 , Julie Pires DA Silva  2 , Shriprasad R Deshpande  6 , Jessica Hoover  7 , Kimberly Y Lin  8 , Shelley D Miyamoto  2 , Kriti Puri  9 , Jack Price  9 , Joseph Spinner  9 , Rachel White  8 , Joseph W Rossano  8 , David W Bearl  10 , Melissa K Cousino  11 , Perry Catlin  12 , Nicolas Corral Hidalgo  13 , Justin Godown  10 , Paul Kantor  14 , Daniele Masarone  15 , David M Peng  11 , Kelly E Rea  11 , Kurt Schumacher  11 , Robert Shaddy  14 , Erin Shea  15 , Henry Valora Tapia  16 , Nishma Valikodath  9 , Farhan Zafar  17 , Daphne Hsu  13
Affiliations
Review

Research Gaps in Pediatric Heart Failure: Defining the Gaps and Then Closing Them Over the Next Decade

Shahnawaz Amdani et al. J Card Fail. 2024 Jan.

Abstract

Given the numerous opportunities and the wide knowledge gaps in pediatric heart failure, an international group of pediatric heart failure experts with diverse backgrounds were invited and tasked with identifying research gaps in each pediatric heart failure domain that scientists and funding agencies need to focus on over the next decade.

Keywords: Pediatric; big data; chronic management; definition; discharge planning; future; genetics; heart failure; management; mechanisms; outpatient; presentation; wearables.

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Conflict of interest statement

DECLARATION OF COMPETING INTEREST S.A. is a site PI for a multicenter study led by the University of Michigan (reports no salary support). J.H. is the president of the Ohio College of Clinical Pharmacy and reports reimbursement for attending the annual meeting. S.C. reports honoraria for her speaking engagements by Enduring Hearts. J.R. is a consultant for Bayer, Merck, Bristol Myers Squibb, CRI Biotech, and American Regent; and reports payment for medical legal review. J.S. serves on the leadership committee for the Advanced Cardiac Therapies Improving Outcomes Network (ACTION). J.P. is a board member for the myocarditis foundation. S.M. is funded by the NIH/NHLBI, American Heart Association, and Additional Ventures; patents issued: CU2150H (Co-inventor for: “microRNA expression in pediatric heart failure patients), CU2650H (Co-inventor for: “Selective Inhibition of Beta-Adrenergic Receptors for the Treatment of Pediatric Heart Failure), patent pending: CU3250H (Co-inventor for: “microRNAs as a Prognostic Biomarker in Pediatric Heart Failure); and serves on the advisory board for Children's cardiomyopathy foundation, and Additional Ventures. K.L. serves as Chair of the Pediatric heart failure committee, American Heart Association Young Hearts Council. J.C. serves on the DSMB for the PumpKIN and reports unrestricted educational grant from Abbott. M.K.C. receives research funding and salary support from NHLBI (5K23HL145096), reports funding from Additional Ventures and Enduring Hearts, and serves on leadership for ISHLT, Transplant Families, Enduring Hearts. and ACTION. F.Z. reports research funding from National Institutes of Health (R01HL147957) and has stock in TransMedics, Inc. R.S. reports consulting fees from Novartis, CRI Biotech, American Regent, and Rocket Pharmaceuticals. K.S. serves on the scientific advisory board for Enduring Hearts. D.P. serves on the DSMB for Berlin EXCOR Active Driving system study. J.G. reports consulting fees from Daiichi Sankyo and has stock in Abbott. M.C. is funded by NIH/NHLBI, Additional Ventures, and Enduring Hearts. The other authors report no conflicts/disclosures.

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