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Comparative Study
. 1987 Jan;30(1):205-8.
doi: 10.1021/jm00384a035.

Substituted 2-(2-hydroxyphenyl)benzimidazoles as potential agents for the control of periodontal diseases

R A Coburn, M T Clark, R T Evans, R J Genco
Comparative Study

Substituted 2-(2-hydroxyphenyl)benzimidazoles as potential agents for the control of periodontal diseases

R A Coburn et al. J Med Chem. 1987 Jan.

Abstract

A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.

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