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Review
. 2023 Dec 8;9(1):95.
doi: 10.1038/s41522-023-00463-8.

Recent advances in single-cell engineered live biotherapeutic products research for skin repair and disease treatment

Muhamad Aidilfitri Mohamad Roslan  1 , Mohd Norfikri Omar  1 , Nur Azlina Mohd Sharif  2 , Nurul Hanun Ahmad Raston  2 , Mohd Hafiz Arzmi  3   4 , Hui-Min Neoh  5 , Ahmad Bazli Ramzi  6
Affiliations
Review

Recent advances in single-cell engineered live biotherapeutic products research for skin repair and disease treatment

Muhamad Aidilfitri Mohamad Roslan et al. NPJ Biofilms Microbiomes. .

Abstract

The human microbiome has emerged as a key player in maintaining skin health, and dysbiosis has been linked to various skin disorders. Amidst growing concerns regarding the side effects of antibiotic treatments, the potential of live biotherapeutic products (LBPs) in restoring a healthy microbiome has garnered significant attention. This review aims to evaluate the current state of the art of the genetically or metabolically engineered LBPs, termed single-cell engineered LBPs (eLBPs), for skin repair and disease treatment. While some studies demonstrate promising outcomes, the translation of eLBPs into clinical applications remains a significant hurdle. Substantial concerns arise regarding the practical implementation and scalability of eLBPs, despite the evident potential they hold in targeting specific cells and delivering therapeutic agents. This review underscores the need for further research, robust clinical trials, and the exploration of current advances in eLBP-based bioengineered bacterial chassis and new outlooks to substantiate the viability and effectiveness of eLBPs as a transformative approach in skin repair and disease intervention.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Intervention strategies through microbiome engineering for addressing prevalent skin conditions and diseases (therapeutic targets) using live biotherapeutic products.
Fig. 2
Fig. 2
Schematic illustration and therapeutic strategy of engineered live biotherapeutic products (eLBPs) in treating skin conditions and dysbiosis such as cutaneous wounds and malignant melanoma.
See this image and copyright information in PMC

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