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. 2023 Dec;513(1):332-336.
doi: 10.1134/S1607672923700539. Epub 2023 Dec 8.

Chromatin Remodeling Complex PBAF Activates and Represses Inflammatory Genes

A V Feoktistov  1   2 , S G Georgieva  3 , N V Soshnikova  3   4
Affiliations

Chromatin Remodeling Complex PBAF Activates and Represses Inflammatory Genes

A V Feoktistov et al. Dokl Biochem Biophys. 2023 Dec.

Abstract

The PBAF chromatin remodeling complex regulates chromatin state and gene transcription in higher eukaryotes. In this work, we studied the role of PBAF in the regulation of NF-κB-and JAK/STAT-dependent activation of inflammatory genes. We performed knockdown of specific module subunit BAF200, which resulted in destruction of the entire PBAF specific module and changed the level of the genes transcription of both pathways. PBAF can be both an activator and a repressor of inflammatory genes. Thus, PBAF is an important regulator of inflammatory gene expression.

Keywords: Jak/STAT; NF-kB; SWI/SNF; eukaryotic transcription factors; gene expression; inflammation.

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References

REFERENCES

    1. Yuan, J. et al., Structure of human chromatin-remodelling PBAF complex bound to a nucleosome, Nature, 2022. vol. 605, pp. 166–1171. - DOI - PubMed
    1. Centore, R.C. et al., Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies, Trends Genet., 2020, vol. 36, no. 12, pp. 936–950. - DOI - PubMed
    1. Ishizaka, A. et al., Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-κB RelA/p50 heterodimer, J. Biol. Chem., 2012, vol. 287, no. 15, pp. 11924–11933. - DOI - PubMed - PMC
    1. Ramirez-Carrozzi, V.R. et al., A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling, Ciell, 2009, vol. 138, no. 1, pp. 114–128. - DOI
    1. Natoli, G., NF-κB and chromatin: ten years on the path from basic mechanisms to candidate drugs, Immunol. Rev., 2012, vol. 246, no. 1, pp. 183–192. - DOI - PubMed

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