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. 2023 Dec;24(6):289-291.
doi: 10.1038/s41435-023-00231-w. Epub 2023 Dec 8.

Interleukin-3 gets a fresh start in the brain

Abi G Yates  1   2 , Annie Khamhoung  1   2 , Cameron S McAlpine  3   4
Affiliations

Interleukin-3 gets a fresh start in the brain

Abi G Yates et al. Genes Immun. 2023 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1. The role of IL-3 signaling in Alzheimer’s disease and multiple sclerosis.
In Alzheimer’s disease (AD), IL-3 is generated by astrocytes and signals to microglia via IL-3Rɑ to instigate cell motility and migratory programming which enables microglia to cluster and clear of β-amyloid, resolving disease. In multiple sclerosis (MS), IL-3 is produced by astrocytes and infiltrating T cells where is signals to microglia and peripherally derived myeloid cells via IL-3Rɑ to promote the generation of chemotactic cues and migratory programing that perpetuates immune cell recruitment to the central nervous system (CNS), worsening MS.
See this image and copyright information in PMC

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