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Review
. 2023 Nov 26;12(23):2712.
doi: 10.3390/cells12232712.

Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies

Siqi Zheng  1 , Erika Guerrero-Haughton  1   2   3 , Floris Foijer  1
Affiliations
Review

Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies

Siqi Zheng et al. Cells. .

Abstract

Chromosomal instability (CIN) is a prevalent characteristic of solid tumours and haematological malignancies. CIN results in an increased frequency of chromosome mis-segregation events, thus yielding numerical and structural copy number alterations, a state also known as aneuploidy. CIN is associated with increased chances of tumour recurrence, metastasis, and acquisition of resistance to therapeutic interventions, and this is a dismal prognosis. In this review, we delve into the interplay between CIN and cancer, with a focus on its impact on the tumour microenvironment-a driving force behind metastasis. We discuss the potential therapeutic avenues that have resulted from these insights and underscore their crucial role in shaping innovative strategies for cancer treatment.

Keywords: cancer therapy; chromosomal instability; extracellular matrix; extracellular vesicles; immune modulation; metabolic vulnerabilities; metastasis; tumour microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular mechanisms that underly the relationship between CIN and metastasis. cGAS-STING signalling mediates immune modulation in response to DNA leakage, connecting inflammation, genetic diversity, and metastasis, and providing potential therapeutic targets.
Figure 2
Figure 2
Strategies for targeting chromosomal instability (CIN)-driven cancer. This diagram provides an overview of potential strategies for targeting CIN-driven cancer.
See this image and copyright information in PMC

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