Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 22;28(23):7719.
doi: 10.3390/molecules28237719.

The Potential of Glycyrrhiza from "Medicine Food Homology" in the Fight against Digestive System Tumors

Doudou Lu  1 , Yating Yang  2 , Yuhua Du  3 , Lei Zhang  4 , Yi Yang  5 , Joanna Japhet Tibenda  3 , Yi Nan  4 , Ling Yuan  3
Affiliations
Review

The Potential of Glycyrrhiza from "Medicine Food Homology" in the Fight against Digestive System Tumors

Doudou Lu et al. Molecules. .

Abstract

Glycyrrhiza has a long history of applications and a wide range of pharmacological effects. It is known as the "king of all herbs". Glycyrrhiza is effective in clearing heat, detoxifying, relieving cough, and tonifying qi and has good bioactivity in multiple inflammatory, immune, and tumor diseases. This review aims to summarize the origin, distribution, and anti-digestive system tumor mechanism of glycyrrhiza and its homologous applications in medicine and food. The active compounds include triterpenoids, flavonoids, and coumarins, which are widely used in clinical treatments, disease prevention, and daily foods because of their "enhancement of efficacy" and "reduction of toxicity" against digestive system tumors. This paper reviews the use of glycyrrhiza in digestive system tumors and provides an outlook on future research and clinical applications.

Keywords: anti-tumor; digestive system cancer; glycyrrhiza; medicine food homology; natural distribution; pharmacology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Number of glycyrrhiza patent applications from 2013 to 2023.
Figure 2
Figure 2
The research process of this review.
Figure 3
Figure 3
Distribution of glycyrrhiza in world and China. Green areas represent areas where three kinds of glycyrrhiza are grown, red represents China, and red lines represents areas where three kinds of glycyrrhiza are grown in China.
Figure 4
Figure 4
The active compounds in glycyrrhiza.
Figure 5
Figure 5
Screening of the related targets and pathways of glycyrrhiza.
Figure 6
Figure 6
Synergistic and attenuated effects of glycyrrhiza on digestive tumors.
Figure 7
Figure 7
The process of apoptosis regulated by glycyrrhiza.
Figure 8
Figure 8
The process of EMT regulated by glycyrrhiza.
Figure 9
Figure 9
The process of autophagy regulated by glycyrrhiza.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Nagtegaal I.D., Odze R.D., Klimstra D., Paradis V., Rugge M., Schirmacher P., Washington K.M., Carneiro F., Cree I.A. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76:182–188. doi: 10.1111/his.13975. - DOI - PMC - PubMed
    1. Fang S.G., Wei J.G., Chen Z.W., WHO Differentiation of tumors in the digestive system is still uncertain. Chin. J. Clin. Exp. Pathol. 2019;26:865–870.
    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Lugones Y., Loren P., Salazar L.A. Cisplatin Resistance: Genetic and Epigenetic Factors Involved. Biomolecules. 2022;12:1365. doi: 10.3390/biom12101365. - DOI - PMC - PubMed
    1. Santos N., Ferreira R.S., Santos A. Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents. Food Chem. Toxicol. 2020;136:111079. doi: 10.1016/j.fct.2019.111079. - DOI - PubMed

LinkOut - more resources