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. 2023 Nov 21;16(23):7257.
doi: 10.3390/ma16237257.

Development of Novel Composite Biocompatible Materials by Surface Modification of Porous Inorganic Compounds Using Bambus[6]Uril

Gulstan Zhumabayeva  1 , Pana Turebayeva  1 , Arthur Ukhov  2 , Dmitry Fedorishin  2 , Alexander Gubankov  2 , Venera Luchsheva  2 , Irina Kurzina  2 , Abdigali Bakibaev  2 , Roza Ryskaliyeva  3 , Gulnara Abdullina  4 , Saltanat Bolysbekova  5 , Rakhmetulla Yerkassov  1
Affiliations

Development of Novel Composite Biocompatible Materials by Surface Modification of Porous Inorganic Compounds Using Bambus[6]Uril

Gulstan Zhumabayeva et al. Materials (Basel). .

Abstract

In this present investigation, a novel series of composite materials based on porous inorganic compounds-hydroxyapatite and diatomite-have been innovatively formulated for the first time through surface modification employing the promising macromolecular compound, bambus[6]uril. The process entailed the application of a bambus[6]uril dispersion in water onto the surfaces of hydroxyapatite and diatomite. Extensive characterization was carried out, involving IR spectroscopy and SEM. The materials underwent assessment for hemolytic effects and plasma protein adsorption. The results revealed that materials containing surface-bound bambus[6]uril did not demonstrate inherent hemolytic effects, laying a robust groundwork for their use as biocompatible materials. These findings hold significant promise as an alternative pathway for the development of durable and efficient bio-composites, potentially unveiling supramolecular strategies incorporating encapsulated bambus[6]urils in analogous processes.

Keywords: bambus[6]urils; biocompatible materials; diatomite; hemolytic effect; hydroxyapatite; plasma protein adsorption.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Visual Representation of the Bu[6] Application onto HA and DA Surfaces.
Figure 2
Figure 2
Diffractogram of synthesized stoichiometric HA (blue line stands for standard data and red line stands for experimental data).
Figure 3
Figure 3
Illustration of the Deposition Method of Bu[6] onto HA and DA.
Figure 4
Figure 4
Infrared Spectra of Samples: Bu[6], HA + BU[6], HA.
Figure 5
Figure 5
Infrared Spectra of Samples: Bu[6], IDA + Bu[6], IDA.
Figure 6
Figure 6
Infrared Spectra of Samples: Bu[6], CDA + Bu[6], CDA.
Figure 7
Figure 7
SEM Image of the HA (A) and Bu[6] + HA samples with varying resolution (B,C), highlighting the conglomerate of Bu[6] molecule ensembles in a red square.
Figure 8
Figure 8
SEM image of the IDA (A) and Bu[6] + IDA sample with varying resolution (B,C), highlighting the conglomerate of Bu[6] molecule ensembles in a red square.
Figure 9
Figure 9
SEM image of the CDA (A) and Bu[6] + CDA samples with varying resolution (B,C), highlighting the conglomerate of Bu[6] molecule ensembles in a red square.
See this image and copyright information in PMC

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